Protein Info for RR42_RS34290 in Cupriavidus basilensis FW507-4G11

Annotation: penicillin-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 643 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00912: Transgly" amino acids 58 to 230 (173 residues), 207.7 bits, see alignment E=9.7e-66 TIGR02074: penicillin-binding protein, 1A family" amino acids 66 to 595 (530 residues), 596.1 bits, see alignment E=3.6e-183 PF00905: Transpeptidase" amino acids 325 to 560 (236 residues), 108.7 bits, see alignment E=3.3e-35

Best Hits

KEGG orthology group: None (inferred from 78% identity to rme:Rmet_3992)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YUZ3 at UniProt or InterPro

Protein Sequence (643 amino acids)

>RR42_RS34290 penicillin-binding protein (Cupriavidus basilensis FW507-4G11)
MKRVVAKAASVALALAAASTLLVGFAAVVSLRQLPAVDALRDYRPDLPLRIFTSDNVLIG
EFGTEHREFVPLERMPKQMSNALLAAEDDQFYQHAGVDIPGIFRAALANIGEGYAQGAST
ITMQVARNFYLSREKTLSRKWYEILLAWKIDRSLPKDRILELYMNQVYLGEHAYGFGSAA
QAYFGKPLDALSLAETAMLAGLPKAPSTMNPVVNFPRAKLRQQYVLGRMQALGMISHQQY
QAARAQTLQVAGSHNGRFDGHAEYVAELARQLAYDRFGEAAYTRGLNVYTTVSSVRQSLA
YEAVHAGLDQYGKRHGQQAAPQAALVSLDSRSGAIEAMIGGADFATSRFNHATQALRQPG
STFKPFIYSAALERGVSATTLINDAPLDASSRWQPGNDDGRFLGAVSVRQALAESRNLPA
IRTLQTIGIPYAVDYAGKFGFSEQRLPRYLPLALGTGTTTPLRLAAAYGVFASEGYRTEP
YLIERISDGAGNVLFSADSEPQPHRVIPERNAYVMNSLLRSVVTSGTGAGLQRYLRRADV
AGKTGTTNDSVDGWFAGYASGIVTVAWMGFDDNRSLGRHEFGATTALPIWASYMEGRLAG
QPEAEFVAPRNLVRSGDDWVYPEYADGSHGIAALGFPSAPADA