Protein Info for RR42_RS33765 in Cupriavidus basilensis FW507-4G11

Annotation: cobalt chelatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 573 PF06213: CobT" amino acids 19 to 231 (213 residues), 80.6 bits, see alignment E=1.5e-26 PF11775: CobT_C" amino acids 355 to 549 (195 residues), 170.7 bits, see alignment E=3.8e-54

Best Hits

KEGG orthology group: K09883, cobaltochelatase CobT [EC: 6.6.1.2] (inferred from 75% identity to bxe:Bxe_B0688)

Predicted SEED Role

"Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2)" in subsystem Coenzyme B12 biosynthesis or Conenzyme B12 related Hypothetical: Clusters with cobST (EC 6.6.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.6.1.2

Use Curated BLAST to search for 6.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YMN8 at UniProt or InterPro

Protein Sequence (573 amino acids)

>RR42_RS33765 cobalt chelatase (Cupriavidus basilensis FW507-4G11)
MPPPRQAARRGQQREALCAAVVRALTGERALHYRDGRLCRDLRPLPLHAPHLRTDPQVDD
FACLRGAADGAALRLAHSDADLHKQLCPADPVERLVFELLEQLRCESQLPAGMPGVAQNL
RHRFAAWSRGFHRSGLAESHLGILLYTVAQIAWSRLSGWPVLEDTEDLIEATRAAIVPVL
GVPLAGLRRHRAEQGAFAIHALELARLVGEMLRATRTHGTQADEQEAEDNEAVRVAFSLA
LGCEDDELDAMAMAATGNSRVLHACGHGYRAYTTRYDREIAPGTLVRKDLLAAYRERLDQ
RIAEQGINVARLARALTASLAVPQRDGWSFGEEDGRIDGRRLAQLVTSPAERRLFRQERH
QLQADCAVSFLIDCSGSMKAHIEPVAMMVDILTRALDQAGVASEVLGFTTGAWNGGRARL
DWLARGRPAHPGRLNEACHMVFKDAATSWRRARANIAALFKADLFREGVDGEAVDWACAR
LLARAETRRILIVVSDGSPMDSATGQANDVFYLDNHLKEVVARHETLRDVEVLGLGVGLD
LSPYYRRCLALDLSVPMDMPVFGEIVRWIGGRR