Protein Info for RR42_RS33290 in Cupriavidus basilensis FW507-4G11

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 658 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 281 to 299 (19 residues), see Phobius details PF08448: PAS_4" amino acids 374 to 480 (107 residues), 39.5 bits, see alignment E=8.6e-14 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 485 to 648 (164 residues), 136.2 bits, see alignment E=4.4e-44 PF00990: GGDEF" amino acids 490 to 646 (157 residues), 154.4 bits, see alignment E=3.5e-49

Best Hits

KEGG orthology group: None (inferred from 65% identity to reh:H16_A2497)

Predicted SEED Role

"Sensory box/GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YMG4 at UniProt or InterPro

Protein Sequence (658 amino acids)

>RR42_RS33290 histidine kinase (Cupriavidus basilensis FW507-4G11)
MRHSLKYQVALATALVVTFVIVARALFSQYYAFQSLTALRQSQQETLVKLVAEQLDEKFE
TRAIALRRLARQLAPMLGQPPADLRRFASQAMSMPQFFNAVFLALPDGDMVFSTAVPVGQ
RIHLSDRDYFRAVVDGSEFAVSDLLRGRMSDSPGVVLAVPLRGADGKLLAVVGGVLNFSE
SNFLSVLAHSRVGLTGGYCLVSSGTNPRYAMHPDPSKVMMPAKAHGETCGVGAPPTGWEL
LNPTQPVVARYLLESNGWEVVSVLPAAEAYAPLLAARNKTIIVGGMSLLLAALLMWLVIR
RLLAPLELLHRVVSEVPKNPAALAALPTGGNNEIGELAATFGAVMHQLSEREAALSAAKD
CAAESEKRIEAIANHVPDLVSFIDMNERYVFVNEAYAQRFNLPVQQIVGLTMRELWGTSV
YVASKPYLEQAYLGASVTFSLEGKDNAECMQVTYQPAWNDGKDTVQGLYMFARNVTSERQ
KMRSLEAQTLTDHLTGLLNRKGFDRRMADAMARAGANHASAALLLVDVDDFKTINDTFGH
AVGDQLLASFAERLSACVRTGDAVARIGGDEFGIVLDDALNVATLERIAQAIVHAARRAH
FIDGHTIVATASVGMAIHYPDDGQTANELFMRADMALYEAKRGGKARYTPPPASSNRA