Protein Info for RR42_RS32960 in Cupriavidus basilensis FW507-4G11

Annotation: 2-dehydropantoate 2-reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 304 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF02737: 3HCDH_N" amino acids 2 to 40 (39 residues), 24.5 bits, see alignment 4.5e-09 TIGR00745: 2-dehydropantoate 2-reductase" amino acids 2 to 303 (302 residues), 250.9 bits, see alignment E=8.6e-79 PF02558: ApbA" amino acids 3 to 149 (147 residues), 140.6 bits, see alignment E=6.5e-45 PF08546: ApbA_C" amino acids 178 to 302 (125 residues), 121 bits, see alignment E=8.4e-39

Best Hits

KEGG orthology group: K00077, 2-dehydropantoate 2-reductase [EC: 1.1.1.169] (inferred from 66% identity to bcj:BCAL2794)

Predicted SEED Role

"2-dehydropantoate 2-reductase (EC 1.1.1.169)" in subsystem Coenzyme A Biosynthesis (EC 1.1.1.169)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.169

Use Curated BLAST to search for 1.1.1.169

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YM76 at UniProt or InterPro

Protein Sequence (304 amino acids)

>RR42_RS32960 2-dehydropantoate 2-reductase (Cupriavidus basilensis FW507-4G11)
MKIAILGAGAMGSLFGARLAEAGHAVTLLDINDAHLDAIRRFGLRLQTDEADRRVHGMRA
LRPEQADAIPELLIVFTKSMHTRAAMAGVRHLLGPDTTVLSLQNGLGSVDAICEFVPAQR
LLIGVTTWPADLVGPGHVHSHGEGGIRMMSADGVDRPAVAGTVAALERAGLHCTADADVW
AAIWEKVAFNAALNPLCAVTGSTVDQLGNIPDGTALALAVVAEVLAVARSQGVAVDAGKV
GANVLHAIGHHIGHKPSMLQDILAARRTEIDAINGAVVAAARRSGVPVPCTESLLQLVRL
IEAR