Protein Info for RR42_RS32915 in Cupriavidus basilensis FW507-4G11

Annotation: GDP-mannose dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 transmembrane" amino acids 137 to 148 (12 residues), see Phobius details amino acids 168 to 189 (22 residues), see Phobius details PF03446: NAD_binding_2" amino acids 2 to 156 (155 residues), 123.5 bits, see alignment E=1.3e-39 PF03807: F420_oxidored" amino acids 2 to 91 (90 residues), 32 bits, see alignment E=2.4e-11 PF14833: NAD_binding_11" amino acids 163 to 279 (117 residues), 82.6 bits, see alignment E=4e-27

Best Hits

KEGG orthology group: None (inferred from 74% identity to reu:Reut_B4130)

Predicted SEED Role

"3-hydroxyisobutyrate dehydrogenase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YQ17 at UniProt or InterPro

Protein Sequence (292 amino acids)

>RR42_RS32915 GDP-mannose dehydrogenase (Cupriavidus basilensis FW507-4G11)
MQIGFIGIGKMGLPMGRHLAAAGHAVEGFDLSPAVLEAARQAGLKTTGSLAQATAGKDVV
FSSLPHDAAFEAVGAQVAELAAPGTLYIDTSTVSPQASARVAAVLAQRNIPYLRVTVSGN
NKMAEAAQLTALVSGPAAAYAVAKPLLAALGPAQFYLGEAEQARLMKLVVNLMIGLTSGM
LAEALALGAKGGLKWQDMWSVITASAVAAPIVKAKSAQLVENDYTPTFTVDQMLKDVGLI
LEAGADLRVPLSLTALLGQMLQGAAAQGMAGDDYAAVIKSARLAAGLPSVNG