Protein Info for RR42_RS32865 in Cupriavidus basilensis FW507-4G11

Annotation: 4-coumarate--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 514 transmembrane" amino acids 215 to 230 (16 residues), see Phobius details PF00501: AMP-binding" amino acids 15 to 367 (353 residues), 255.7 bits, see alignment E=6.6e-80 PF13193: AMP-binding_C" amino acids 423 to 497 (75 residues), 59.5 bits, see alignment E=5e-20

Best Hits

KEGG orthology group: None (inferred from 66% identity to vap:Vapar_4884)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YQ07 at UniProt or InterPro

Protein Sequence (514 amino acids)

>RR42_RS32865 4-coumarate--CoA ligase (Cupriavidus basilensis FW507-4G11)
MAQPIGNLADCVRLHAAERPGHVAVVDSRGSLTYAEFDALADRVAAALQRDGLQPGASLA
ICAAASIEYAAILIGGLRAGVALVPLAPSSTPASLAGMVEDSDARVLFVDADVLREIAPV
KDNIQARLIGLAGAPAGLAFEAWLAPHGSRPQAHAIAPQQVFNIIYSSGTTGTPKGIVHA
HALRWNQIRRVQESGGYGPDAVTLISTPLYSNTTLVSFIPTLALGGTAVLMPKFDAQRYL
QLAAQYRVTHSMLVPVQYQRLMARADFGDYDLSSYRMKFSTSAPLSAALKAEILKRWPGG
LVEYYGMTEGGGSCVLAAHEFPNKLHTVGKPMEGHDIRLIDDDGKEVPVGEIGEVVGHSN
AIMAGYHKQPEKTSAAEWRDATGKLFIRTGDVGRFDEDGFLTLMDRKKDMIISGGFNIYP
SDLEGILQQHPEVLDCAVVGVPSQRWGETPVAFVVRRDGATVSDDALMAWTNEQVGKTQR
LAVLELVDVLPRSAIGKVLKRELRDGFRPGRPLD