Protein Info for RR42_RS32585 in Cupriavidus basilensis FW507-4G11

Annotation: cytochrome C oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02847: cytochrome o ubiquinol oxidase subunit IV
  • amino acids 24 to 119 (96 residues), 133.9 bits, E=1.1e-43
• PF03626: COX4_pro
  • amino acids 31 to 104 (74 residues), 63.8 bits, E=7.9e-22

Best Hits

Swiss-Prot: 54% identical to CYOD_ECO57: Cytochrome bo(3) ubiquinol oxidase subunit 4 (cyoD) from Escherichia coli O157:H7

KEGG orthology group: K02300, cytochrome o ubiquinol oxidase operon protein cyoD (inferred from 69% identity to rso:RSc2914)

MetaCyc: 54% identical to cytochrome bo3 subunit 4 (Escherichia coli K-12 substr. MG1655)
RXN-21817 [EC: 7.1.1.3]

Predicted SEED Role

"Cytochrome O ubiquinol oxidase subunit IV (EC 1.10.3.-)" in subsystem Terminal cytochrome O ubiquinol oxidase or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

• NADH to cytochrome bo oxidase electron transfer I (2/2 steps found)
• NADH to cytochrome bo oxidase electron transfer II (2/2 steps found)
• glycerol-3-phosphate to cytochrome bo oxidase electron transfer (2/2 steps found)
• proline to cytochrome bo oxidase electron transfer (2/2 steps found)
• succinate to cytochrome bo oxidase electron transfer (2/2 steps found)
• D-lactate to cytochrome bo oxidase electron transfer (1/2 steps found)
• pyruvate to cytochrome bo oxidase electron transfer (1/2 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.3

Sequence Analysis Tools

See A0A0C4YLX5 at UniProt or InterPro

Protein Sequence (121 amino acids)

>RR42_RS32585 cytochrome C oxidase (Cupriavidus basilensis FW507-4G11)
MEHSNVSAAVAHDAHGTTSAGASHGSVKSYVIGFVLAVILTVIPFKLVMGGTLEASTTLA
VILGLAVVQIVVHLIYFLHLDSSSEQRWNVMALAFTALILLIVVAGSLWIMHNMNANMMV
H