Protein Info for RR42_RS32480 in Cupriavidus basilensis FW507-4G11
Annotation: 4-hydroxyphenylpyruvate dioxygenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 39% identical to PCAU_ACIAD: Pca operon regulatory protein (pcaU) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
KEGG orthology group: K02624, IclR family transcriptional regulator, pca regulon regulatory protein (inferred from 87% identity to reu:Reut_B5034)Predicted SEED Role
"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4YE90 at UniProt or InterPro
Protein Sequence (255 amino acids)
>RR42_RS32480 4-hydroxyphenylpyruvate dioxygenase (Cupriavidus basilensis FW507-4G11) MDKEPLSRRDWIAGLEKGLAILEAFDNDHPRLTPTQAAQLTGLTRTAARRYLLTLEHLGY TTSDGTLFSLTPRVLKVGWSYFDSARLPRTVQPFLQQITAAVGEPAYLSVLDDWELVFIC RTGTSRVMNTGFVLGARVPAPLASSGLMMLASEPEEKVKAWLEGCVLTPYTPHTILQQDR LMAEIRRAGAQGYALVEQQLQIGVRGVAVPLRDRHGKVIAALSVNMQIGDESAEQALERV LRVLQDTAISIMRVL