Protein Info for RR42_RS31415 in Cupriavidus basilensis FW507-4G11

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1832 PF00069: Pkinase" amino acids 54 to 263 (210 residues), 83.9 bits, see alignment E=7.5e-27 PF07714: PK_Tyr_Ser-Thr" amino acids 102 to 259 (158 residues), 45.7 bits, see alignment E=3.3e-15 PF13191: AAA_16" amino acids 302 to 491 (190 residues), 148.6 bits, see alignment E=1.5e-46 PF13185: GAF_2" amino acids 1318 to 1461 (144 residues), 44.6 bits, see alignment E=1e-14 PF01590: GAF" amino acids 1318 to 1460 (143 residues), 53.1 bits, see alignment 3e-17 PF13492: GAF_3" amino acids 1318 to 1461 (144 residues), 37.4 bits, see alignment E=1.9e-12 TIGR00229: PAS domain S-box protein" amino acids 1471 to 1594 (124 residues), 56.8 bits, see alignment 1.2e-19 PF13188: PAS_8" amino acids 1475 to 1534 (60 residues), 31.1 bits, see alignment (E = 1e-10) PF00989: PAS" amino acids 1476 to 1577 (102 residues), 38 bits, see alignment 8.9e-13 PF13426: PAS_9" amino acids 1487 to 1586 (100 residues), 45.3 bits, see alignment 5.4e-15 PF00512: HisKA" amino acids 1611 to 1676 (66 residues), 28.8 bits, see alignment (E = 6.2e-10) PF02518: HATPase_c" amino acids 1721 to 1831 (111 residues), 73 bits, see alignment 1.6e-23

Best Hits

KEGG orthology group: None (inferred from 62% identity to bge:BC1002_4951)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YDQ7 at UniProt or InterPro

Protein Sequence (1832 amino acids)

>RR42_RS31415 histidine kinase (Cupriavidus basilensis FW507-4G11)
MNPLFYFGHESGVSFPVVWEDDDRVVGRGWLPGRDGMPKAVLAVWHAAEHPRPTSLAHEY
GLKDELDGSWAVRPLELVRERGRTVLLLDDPGGEPLAKLLGTPMEVGRFLRLAISIAAAL
DQFHQRGLIHKDIKPAHILVNDAPIEARLTGFGIASRQSRERQAPAPPEEIAGTLAYMAP
EQTGRMNRSIDARSDLYSLGVTLYQMLTGVLPFATDDPMELLHSHLARQPVPPAERVPSI
PALLSAMVMKLLSKTAEERYQTAAGLEADLRRSSVAWESRGSIATFPLGEHDLPDRPLIP
ERLYGREREIETLLAAFDRVVTQGTPELVLVSGYAGIGKTSAVLALRSALALRNGLFASG
KFDQYKRDVPYATLAQAFQNLVRPLLGKSEADLAPWRTALAEALGPNGGLMVPLIPELGL
ILGPQSPVPELPPCDEQHRFQMVFQRLLAVFAQPTHPLALFLDDLQWLDAATLDLLEYLA
TQPEVRHVLLIGAYRNDDVKPGHPLLLRLPAIRQAGGRVNDITLSPLGFDDVIRLIVDAL
HCAPGDAAPLARLVQEKTGGNPFFAIQFLTALTEEGLLVFDHRGARWSWDLEQIRAKGFT
DNVVDLMLAKLRRLPAATRNALKQLACLGNDAAIASLAMVQDASEAELDAALRPAVRAGL
VLRLGNTYRFLHDRIQEAAYALIPEGARPAAHLAIGRRLATGTPPEAIAERVFEIVGQLN
RGTDLITAAEEREQVAELNLLAGQRAKASTAYASALTYLTAGAALMQGDAWKRRPKFAFA
LEFHLAECEFLTGAPAAADARLAELACRAASLPDLASVTQLRLELFLALGQRERAVEVGL
DYLYRAGVQCSAHPTDEEVLQEYDRMWRQLGDRPIEALLDLPMMTNAVACETMDVLTALM
LPAWYTDVNLGSLIIGRMANLSLEQGNSDASCLAYTWLGMILGPRSGDYKAAFRFGQLGL
SLVEQRGLDRFRARVYQAFGGHVMQWTQPIRAARSLVRRAFDVASKLGDLTYASFARNNL
ITQLLACGDPLAEVQNEAEATIGFARRASFGLAVDRVTPQLQLARTLRGLTPVFGVFDDD
DFNEEEFERYLDEAPGPALATCWYWIRKLQARFLADDHAAAIAAADRAESLLWTSPSFFE
QAEYHFYTALARAACCGTAAAPERTQHLAALAAHHRQLLVWSEHCPENFENRAALVGAEI
ARLDGREVDAMGLYEQAIRSAQDNDFIHNQALANELAARFYAARGFEKVARVYLQDARHG
YLRWGAGGKVRQLDALYPHLWGEERAPAPTTTIGAPVEHLDLATVIAVSQAVSGEIVLDK
LLDTLMRTAIEQAGAERGLLILPRGSEQRIAAEATTGGDIVTVQLRDESVTATALPVSML
HYVLRTRENIILDNAATQMPFSDDPYILQHHARSILCLPLLTQAKLVGVLYLENNLAPRV
FVPTRTTVLKMLASQAATALEITCLYRDLAQREAKIQRLVEANIIGICLWHMDGRILEAN
DAFLRMLGYDREDLASVPLRWTDLTPPDRRERDARLVQDLRISGTLPPFEKEFFRKDGSR
VLVLLGCATFEEGGEQGVSYMLDLTERKRAEEALHQAQAELAHVTRVTTLNALTASIAHE
VNQPLAAIVTNANAALRWLARQPPDLAEVRDTLGCIVQDGHRAGAVIEGMRALLKKTAAV
TARLDMNALIEDAIALIQGEISRHQVLLRTELEPDLPPVAGDRVQLQQVLLNLMMNSIEA
MKEVAERPRGLLIRSHLDASGTVLVAVQDAGVGLEPQDLERVFQTFFTTKAEGLGMGLAI
CRLIVEAHGGRLWAYPNVPCGAVFQFTLPPQD