Protein Info for RR42_RS30960 in Cupriavidus basilensis FW507-4G11

Annotation: transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 224 TIGR01387: heavy metal response regulator" amino acids 3 to 219 (217 residues), 346 bits, see alignment E=4.4e-108 PF00072: Response_reg" amino acids 3 to 111 (109 residues), 101.6 bits, see alignment E=2.9e-33 PF00486: Trans_reg_C" amino acids 144 to 219 (76 residues), 87.8 bits, see alignment E=4e-29

Best Hits

Swiss-Prot: 67% identical to IRLR_BURPS: Transcriptional activator protein IrlR (irlR) from Burkholderia pseudomallei (strain K96243)

KEGG orthology group: K07665, two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR (inferred from 89% identity to reh:H16_B1647)

Predicted SEED Role

"DNA-binding heavy metal response regulator" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YSU8 at UniProt or InterPro

Protein Sequence (224 amino acids)

>RR42_RS30960 transcriptional regulator (Cupriavidus basilensis FW507-4G11)
MRILIVEDEPKAGDYLRKGLSESGFVVDLARDGVDGLAHARGQEYDLIVLDVMLPGMDGW
QVLQELRRERDTPVLFLTARDALSDRLKGLELGADDYMVKPFAFAELVMRIRTILRRGPL
RESELIEVADLQIDTVKRRVTRDGQKLELTSKEFALLQLLARRSGEVLSRSLIASHVWDM
NFDSNTNVVDVSIRRLRAKVDDPFPAKLIHTRRGMGYVLEEEVR