Protein Info for RR42_RS30930 in Cupriavidus basilensis FW507-4G11

Annotation: 4-deoxy-4-formamido-L-arabinose-phospho-UDP deformylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 796 transmembrane" amino acids 155 to 175 (21 residues), see Phobius details amino acids 181 to 199 (19 residues), see Phobius details amino acids 211 to 230 (20 residues), see Phobius details amino acids 277 to 294 (18 residues), see Phobius details amino acids 384 to 403 (20 residues), see Phobius details amino acids 415 to 441 (27 residues), see Phobius details amino acids 747 to 764 (18 residues), see Phobius details amino acids 770 to 791 (22 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 213 to 790 (578 residues), 552.8 bits, see alignment E=1.6e-169 TIGR01494: HAD ATPase, P-type, family IC" amino acids 236 to 500 (265 residues), 115.7 bits, see alignment E=2.9e-37 amino acids 550 to 766 (217 residues), 109.9 bits, see alignment E=1.7e-35 PF00122: E1-E2_ATPase" amino acids 264 to 445 (182 residues), 182 bits, see alignment E=1.3e-57 PF00702: Hydrolase" amino acids 462 to 701 (240 residues), 88.4 bits, see alignment E=1.3e-28

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 73% identity to reh:H16_B1644)

MetaCyc: 61% identical to cadmium translocating P-type ATPase (Pseudomonas putida KT2440)
3.6.3.3-RXN [EC: 7.2.2.21]

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5 or 7.2.2.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YNQ9 at UniProt or InterPro

Protein Sequence (796 amino acids)

>RR42_RS30930 4-deoxy-4-formamido-L-arabinose-phospho-UDP deformylase (Cupriavidus basilensis FW507-4G11)
MPSATPDQASLRAPSCCGHGHSDAHEHVHKHDQAHQHDHDHDHGHQRAQAGGAACCGSAS
AAPPIAVAVPAGAAAASYRIDAMDCPTEETLIRNKLGSMAGVAALQFNLMQRVLTVHHTL
DSLEPVVRAIESLGMKAEPLSEQAAALPPQAAKPWWPLALAGAAALGAEAVQWLQVPGQE
WLAPLLALVAVAIAGLGVYKKGWIALSNGNLNINALMSIAVTGAMLIRQWPEAAMVMVLF
ALAERIEAASLDRARNAVRGLMAMAPEQATVRQRDGSWLPVAAGAVAIGALVRLRPGERV
ALDGRVLRGQSTLDQAPITGESVPVDKTVGDVLFAGTINQAGELEYEVTAPASGSTLARI
IHAVEAAQGSRAPTQRFVDRFARIYTPLVFLGAVLVAVVPPLAMDGDWSAWIYKALVLLV
IACPCALVISTPVTIVSGLAAAARRGILIKGGVYLEQGKDLKWLALDKTGTITHGKPAQT
DFQPLGATAAAGAAASDAARVIAASLAARSDHPVSMAVANAARAHGIVPLEVQDFAALPG
YGVSGSVNGRSYYLGNHRLIHDRGLCSPELEATLEAMERQGKTVVLLGADHGVEALFGVA
DTVKDSSREAVAALHSLGVKTLMLSGDNPHTAQAIAAQVQIDEARGNQLPQDKADAIAAL
SVKGAEGAPGNGGNGSNGSKRVVVGMVGDGVNDAPALARADIGFAMGAAGTDTAIETADV
ALMDDDLRKIPAFIRLSRQTSTILKQNIALALGIKAIFLALTVMGLGTMWMAVFADMGAS
LLVVFNGLRLAGRDRS