Protein Info for RR42_RS30135 in Cupriavidus basilensis FW507-4G11

Annotation: sulfatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 PF01663: Phosphodiest" amino acids 3 to 280 (278 residues), 33.9 bits, see alignment E=4.2e-12 PF00884: Sulfatase" amino acids 4 to 335 (332 residues), 139.3 bits, see alignment E=2.6e-44 PF16347: SGSH_C" amino acids 300 to 414 (115 residues), 33.7 bits, see alignment E=6.3e-12

Best Hits

KEGG orthology group: None (inferred from 74% identity to pla:Plav_3641)

Predicted SEED Role

"Choline-sulfatase (EC 3.1.6.6)" in subsystem Choline Transport or Choline and Betaine Uptake and Betaine Biosynthesis (EC 3.1.6.6)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.1.6.6

Use Curated BLAST to search for 3.1.6.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YN97 at UniProt or InterPro

Protein Sequence (506 amino acids)

>RR42_RS30135 sulfatase (Cupriavidus basilensis FW507-4G11)
MRLIYIDIDTLRPDHLGCYGYHRKTSPNIDKLAARSALFRNVHASDTPCLPSRTALLTGR
FGIHNGVVNHGGEDADPVIGGPDRQFWSQLHFDSFPFRLQQAGLKTVSVSSFAHRHSAFH
WYTGFDETYNVGKFGRETADEVHALASDWLARHGKEDNWFLHVHMWDPHTPYRAAPEYGE
PFADDPLPAWLTQEVRAEHWQGCGPHSAQESTGFAPNEAARAWYPRQPQSIPDMAAVRAM
FDGYDTGVLVADEYVGKLLAQLAELGVDGETAVMLSSDHGETLGELSVYGDHQTADQFTT
NVPLLLKWPGIEAGREYRAFHYQIDVTATILELLGQPVPASWDGASFAQSLKAGADEGRD
HLVVSQGAWTCQRGVRFGNWMMICTLHDGYHLFDDVLLFDLEADPHEQRNLADHRPDIVE
KGMGLLRAWEAEMLPTAARGRDPLVNVVKEGGPYHIRGKLRAYLDRLRETGREAKADALA
LKYAEDLQRPAEPGKPPFPIRNLRLV