Protein Info for RR42_RS28390 in Cupriavidus basilensis FW507-4G11
Annotation: acetyl-CoA acetyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.
Best Hits
KEGG orthology group: K00626, acetyl-CoA C-acetyltransferase [EC: 2.3.1.9] (inferred from 94% identity to reu:Reut_B4787)Predicted SEED Role
"Acetyl-CoA acetyltransferase"
MetaCyc Pathways
- oleate β-oxidation (29/35 steps found)
- ketolysis (3/3 steps found)
- polyhydroxybutanoate biosynthesis (3/3 steps found)
- acetoacetate degradation (to acetyl CoA) (2/2 steps found)
- ketogenesis (4/5 steps found)
- acetyl-CoA fermentation to butanoate (5/7 steps found)
- L-glutamate degradation V (via hydroxyglutarate) (7/10 steps found)
- pyruvate fermentation to butanol II (engineered) (4/6 steps found)
- superpathway of Clostridium acetobutylicum acidogenic fermentation (6/9 steps found)
- valproate β-oxidation (6/9 steps found)
- (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) (3/5 steps found)
- glutaryl-CoA degradation (3/5 steps found)
- pyruvate fermentation to acetone (3/5 steps found)
- 2-deoxy-D-ribose degradation II (5/8 steps found)
- L-tryptophan degradation III (eukaryotic) (10/15 steps found)
- (2S)-ethylmalonyl-CoA biosynthesis (2/4 steps found)
- pyruvate fermentation to hexanol (engineered) (7/11 steps found)
- pyruvate fermentation to butanoate (4/7 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (18/27 steps found)
- isopropanol biosynthesis (engineered) (2/5 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (17/26 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (10/17 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (7/13 steps found)
- glycerol degradation to butanol (9/16 steps found)
- pyruvate fermentation to butanol I (3/8 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (10/18 steps found)
- superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (4/10 steps found)
- 2-methylpropene degradation (2/8 steps found)
- ethylmalonyl-CoA pathway (4/11 steps found)
- mevalonate pathway I (eukaryotes and bacteria) (1/7 steps found)
- mevalonate pathway II (haloarchaea) (1/7 steps found)
- L-lysine fermentation to acetate and butanoate (3/10 steps found)
- methyl tert-butyl ether degradation (3/10 steps found)
- 4-oxopentanoate degradation (2/9 steps found)
- L-glutamate degradation VII (to butanoate) (4/12 steps found)
- isoprene biosynthesis II (engineered) (1/8 steps found)
- mevalonate pathway III (Thermoplasma) (1/8 steps found)
- mevalonate pathway IV (archaea) (1/8 steps found)
- benzoate fermentation (to acetate and cyclohexane carboxylate) (7/17 steps found)
- crotonate fermentation (to acetate and cyclohexane carboxylate) (6/16 steps found)
- toluene degradation VI (anaerobic) (5/18 steps found)
- superpathway of ergosterol biosynthesis I (5/26 steps found)
- superpathway of L-lysine degradation (12/43 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)
- superpathway of cholesterol biosynthesis (5/38 steps found)
KEGG Metabolic Maps
- Benzoate degradation via CoA ligation
- Butanoate metabolism
- Fatty acid metabolism
- Lysine degradation
- Propanoate metabolism
- Pyruvate metabolism
- Synthesis and degradation of ketone bodies
- Terpenoid biosynthesis
- Tryptophan metabolism
- Valine, leucine and isoleucine degradation
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.9
Use Curated BLAST to search for 2.3.1.9
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4YMB7 at UniProt or InterPro
Protein Sequence (387 amino acids)
>RR42_RS28390 acetyl-CoA acetyltransferase (Cupriavidus basilensis FW507-4G11) MSLNGSAYIVGAYEHPTRKADDLSVVRLHADVAKGALEDAGLSKGDIDGYFCAGDAPGLG TTTMVEYLGLKVRHVDSTECGGSAPILHVAHAAQAIAAGRCNVALITLAGRPRAAGAALS LKAPDPDAPELAFELPFGPATQNLYGMVAKRHMYEFGTTSEQLAWIKVAASHHAQHNPHA MLRNVVTVEDVVNSPMVSDPLHRLDCCVMSDGGGALIVARPEIAKQLKRPLVKVRGTGEA PKHGMGGKIDLTWSAAAWSGPAAFAEAGVTPADIKYASLYDSFTITVLMQLEDLGFCKKG EGGKFVADGGLISGVGRLPFNTDGGGLCNNHPANRGGVTKVIEAVRQLRGEAHPAVQVKH CDLALASGIGGALASRHTAATLILERV