Protein Info for RR42_RS26175 in Cupriavidus basilensis FW507-4G11

Annotation: gamma-glutamyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 621 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details TIGR00066: gamma-glutamyltransferase" amino acids 69 to 613 (545 residues), 372.1 bits, see alignment E=2e-115 PF01019: G_glu_transpept" amino acids 83 to 616 (534 residues), 491.6 bits, see alignment E=1.6e-151

Best Hits

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 78% identity to reh:H16_A1098)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.2.2

Use Curated BLAST to search for 2.3.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YJA1 at UniProt or InterPro

Protein Sequence (621 amino acids)

>RR42_RS26175 gamma-glutamyltransferase (Cupriavidus basilensis FW507-4G11)
MATQQFSLMRRGSPLALALALLSACSTQTGVSSVPPAQTAPTAAALPAAPEVSSGYRPGM
TTTYADKHMAAAANPLATEAGRKILRAGGTAIDAAVAMQAVLTLVEPQATGIGGGAFIMY
WDGKRVQAYDGRETAPAGASENLFMRPDGKPMSFSEGQIGGRSVGTPGVLRALELAHRQH
GKLPWAKLFEPAIALAEQGFPISPRLYTQIAADKFLPASPEMAAYFLTPDGKPRPVGTML
KNPALAKTLREIARRGPNVLYTGPIASEIVKQVNGSANPGSLSLVDLKDYRAKERAPICS
DYKRWKICGMPPPSSGGIAIAQMLGTLQALEARNPKYALAALKPKQVATPAGVEPGIDAV
HALSEAGRLAYADRGLYVADSDFVPVNVAGLLNRDYLASRASLIGEESMDKAEAGVPPGV
TVALAPDRSPPRVSTSQIVAVDDTGGAISMTTTVESYFGSHLMVRGFVLNNQLTDFSFVP
SENGKPVANRVEPGKRPRSSMAPTLVFDRDSGKLVATVGSPGGSQIIEYVSKTLVGLLDW
NMDVQAAINMPNFGSRNGPTELEAGLVSPALVQGLKDRGHEVAQIEMTSGTQAIMRRQRP
DGTWAWAGGADPRREGVALGD