Protein Info for RR42_RS25465 in Cupriavidus basilensis FW507-4G11

Annotation: long-chain fatty acid--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 transmembrane" amino acids 80 to 99 (20 residues), see Phobius details amino acids 200 to 215 (16 residues), see Phobius details PF00501: AMP-binding" amino acids 29 to 401 (373 residues), 250.6 bits, see alignment E=2.4e-78 PF13193: AMP-binding_C" amino acids 452 to 533 (82 residues), 66 bits, see alignment E=4.7e-22

Best Hits

KEGG orthology group: K00666, fatty-acyl-CoA synthase [EC: 6.2.1.-] (inferred from 55% identity to bcm:Bcenmc03_4347)

Predicted SEED Role

"Medium-chain-fatty-acid--CoA ligase (EC 6.2.1.-)" (EC 6.2.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.-

Use Curated BLAST to search for 6.2.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YHS3 at UniProt or InterPro

Protein Sequence (550 amino acids)

>RR42_RS25465 long-chain fatty acid--CoA ligase (Cupriavidus basilensis FW507-4G11)
MQSSETPSPPAGSQYPLLIKQLLLSPLTQAPDQSIVYRDNHRYTYRALRERIGRLAFGLQ
SLGVGHGDTVAVLDWDSHRYLECFLAVPMMGAVLMTANIRLSPQQLQYTLEQSKPKVLLV
HRDFLELVESFSEVVRNAKCLLILDDEEDCTAAGGYEALLARSRADFRFPDFDENTCATQ
FYTSGTTGLPKGVSYSHRQIVLHTLAVCAAFAMPASQGRFHRGDVYMPLTPMFHVHAWGM
PYVATMMGVKQVYPGRYTPEGILALRAREGVTFSHCVPTILQMLLDRADLDRVGLSGWKI
VVGGASFPTSLASRAMEHGIDAFAGYGMSETCPFVTTSHLGPSLCATDDSAEAMTYRTRA
GRALPLMDIQIVDEAMQPVPEGNHTQGEIVLRAPWLTQAYHMNASATEELWRGGYLHTGD
IGILDEAGYLRITDRLKDVIKTGGEWLSSSTLEDLIRQHQYVREAAVIAVPDSRWGERPM
AIVVATTPSPSSFNAAAIRNHLSDYVTSGHIPKYAIPETIHFVDELPRTSVGKYDKRAMR
ERYQHVRGPS