Protein Info for RR42_RS24770 in Cupriavidus basilensis FW507-4G11
Annotation: NADH:flavin oxidoreductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 42% identical to YQIG_BACSU: Probable NADH-dependent flavin oxidoreductase YqiG (yqiG) from Bacillus subtilis (strain 168)
KEGG orthology group: K00219, 2,4-dienoyl-CoA reductase (NADPH2) [EC: 1.3.1.34] (inferred from 67% identity to bur:Bcep18194_C7286)Predicted SEED Role
"FIG00553873: hypothetical protein"
Isozymes
Compare fitness of predicted isozymes for: 1.3.1.34
Use Curated BLAST to search for 1.3.1.34
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4YKA1 at UniProt or InterPro
Protein Sequence (386 amino acids)
>RR42_RS24770 NADH:flavin oxidoreductase (Cupriavidus basilensis FW507-4G11) MTSEHTTLFHPIAFRNGLTLRNRVVMAPMTTWSANPDGSISDAELDYYRRRVQGVGMVIT GCTHVTENGIGFTDEFAAYDDRFIPSLRRLADAAKSGGAPAVLQIFHAGNKAVVDAVPEG ELVSASAVNALGGPFNRGDVTPRALSQDEILAMVHAFGEATRRAIGAGFDGVELHGAHGF LLQNFFSPRYNQRDDEWGGSQDNRMRFALAVVREAKRVIAAHAKRPFLLGYRISPEERED GGYRVPDICALGDGLIAEGIDYLHVSLNDVLGARPLGTDTRLTVEQVITHVANRVPVLAA GMLRTPEQAQAALDLGLSLVAVGKGLVMNPDWVGLAESGCGAQIRQELDPAERAEWSIPD GLWRAVEAAPGWIPVRQAETVACALG