Protein Info for RR42_RS23065 in Cupriavidus basilensis FW507-4G11

Annotation: L-rhamnose 1-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02746: MR_MLE_N
  • amino acids 39 to 139 (101 residues), 77.2 bits, E=1.2e-25
• PF13378: MR_MLE_C
  • amino acids 162 to 382 (221 residues), 201.7 bits, E=1.3e-63

Best Hits

KEGG orthology group: None (inferred from 96% identity to reh:H16_B0217)

MetaCyc: 84% identical to L-lyxonate dehydratase (Pseudomonas aeruginosa PAO1)
RXN-15590 [EC: 4.2.1.176]

Predicted SEED Role

"Mandelate racemase (EC 5.1.2.2)" (EC 5.1.2.2)

MetaCyc Pathways

• mandelate degradation to acetyl-CoA (15/18 steps found)
• L-lyxonate degradation (3/3 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (25/35 steps found)
• 4-hydroxymandelate degradation (3/6 steps found)
• mandelate degradation I (2/5 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (21/42 steps found)

KEGG Metabolic Maps

• Benzoate degradation via hydroxylation
• Toluene and xylene degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.176 or 5.1.2.2

Sequence Analysis Tools

See A0A0C4Y9C8 at UniProt or InterPro

Protein Sequence (391 amino acids)

>RR42_RS23065 L-rhamnose 1-epimerase (Cupriavidus basilensis FW507-4G11)
MKITNIRTRVFEWKGKTVPPQAHFCTNATDILFERGDAMGSFRFHGWLVVEVETDTGLVG
IGNCALAPRVAKEIIDQYLAPIVIGQDPFDNEYLWQKMYRRTHAWGRKGIGMAAISAVDI
ALWDLMGKAVGKPVFKLLGGRTKEKIWCYASKLYNNDDRDAFLAEAQSYLDQGFTAMKMR
FGYGPKDGPAGMQKNIEQVRLLRELVGDGVDIMLECYMGWTLEYARRMIPRLAEFNPRWL
EEPVIADDIEGYAELKKMSPFPISGGEHEFTSYGFKDLLERRAVDVIQYDTNRVGGITAA
QKINAMAEAWSVPVIPHAGQMHNYHLTMASTASPMSEFFPVHDVEVGNELFYYIFKGEPA
PDNGYLQLDDNLPGLGLTLNEAYFGEFEIIE