Protein Info for RR42_RS21495 in Cupriavidus basilensis FW507-4G11

Annotation: adenosine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 476 PF02805: Ada_Zn_binding" amino acids 7 to 71 (65 residues), 102.6 bits, see alignment E=2.3e-33 PF12833: HTH_18" amino acids 106 to 185 (80 residues), 82.1 bits, see alignment E=7.4e-27 PF00165: HTH_AraC" amino acids 147 to 184 (38 residues), 31.4 bits, see alignment 4.1e-11 PF06029: AlkA_N" amino acids 196 to 310 (115 residues), 114.3 bits, see alignment E=9.6e-37

Best Hits

KEGG orthology group: K13529, AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC: 3.2.2.21] (inferred from 77% identity to reh:H16_B2551)

Predicted SEED Role

"ADA regulatory protein" in subsystem DNA repair, bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.2.2.21

Use Curated BLAST to search for 3.2.2.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y8J8 at UniProt or InterPro

Protein Sequence (476 amino acids)

>RR42_RS21495 adenosine deaminase (Cupriavidus basilensis FW507-4G11)
MKLDPDTCYKAVASHDRRFDGRFFVGVSSTGVYCRPICAVRTPKRENCTFYDSAAAAEKQ
GFRPCLRCRPELAPGHGLADLSGRLAQAAATLIDEGFMVDAGVAGLAARIGITERHLRRL
FDAQFGVSVLEYAQTQRLLLAKRLLTDTGLTVTDVAHAAGFGSVRRFNDVLKTRYGLTPM
AMRKRAADNVADELVFELGYRPPMAWAAFLQFLGVRAVDGIEQLGDGTYARTLAIDSGGR
THVGWLRLEHVARRHVIRVTLSGSLAHVIPQALGRVRRLCDLGCRPDVVDQHLGPLAAEA
PGMRLPGAVDGFEIAVRAVVGQVISVKHARTLLARLAERHGLPLAQPMPALRVTFPGAAT
LAGVPPEALREIGIPLGKGRAIHAIAARVAAGALKLEPDAAPEDTMARLREVEGVGDWTA
QYVAMRALGWPDAFPGTDYVLRKVLGIATVRGMNQHVAQWAPWRAYAAVHLWRRYE