Protein Info for RR42_RS20305 in Cupriavidus basilensis FW507-4G11

Annotation: metal ABC transporter ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 823 transmembrane" amino acids 174 to 192 (19 residues), see Phobius details amino acids 203 to 222 (20 residues), see Phobius details amino acids 235 to 256 (22 residues), see Phobius details amino acids 262 to 280 (19 residues), see Phobius details amino acids 419 to 439 (21 residues), see Phobius details amino acids 445 to 466 (22 residues), see Phobius details amino acids 771 to 789 (19 residues), see Phobius details amino acids 795 to 813 (19 residues), see Phobius details TIGR00003: copper ion binding protein" amino acids 24 to 84 (61 residues), 42.9 bits, see alignment 1.1e-14 amino acids 90 to 152 (63 residues), 32.4 bits, see alignment 2.2e-11 PF00403: HMA" amino acids 25 to 83 (59 residues), 52.8 bits, see alignment 8.5e-18 amino acids 90 to 150 (61 residues), 55.7 bits, see alignment 1e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 218 to 814 (597 residues), 550.2 bits, see alignment E=1.6e-168 TIGR01525: heavy metal translocating P-type ATPase" amino acids 236 to 813 (578 residues), 594.5 bits, see alignment E=6.5e-182 TIGR01494: HAD ATPase, P-type, family IC" amino acids 273 to 519 (247 residues), 141.1 bits, see alignment E=9.7e-45 amino acids 631 to 791 (161 residues), 132.6 bits, see alignment E=3.6e-42 PF00122: E1-E2_ATPase" amino acids 301 to 479 (179 residues), 187.5 bits, see alignment E=3.3e-59 PF00702: Hydrolase" amino acids 496 to 725 (230 residues), 120.2 bits, see alignment E=3e-38

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 80% identity to cti:RALTA_A3123)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YF43 at UniProt or InterPro

Protein Sequence (823 amino acids)

>RR42_RS20305 metal ABC transporter ATPase (Cupriavidus basilensis FW507-4G11)
MPANSRLLPVSGAAAGAPASEWRLPIGGMTCASCVRRVETALGKVPGVRQVAVNLATEEA
TLQADGAAVLPAAAEAVRAAGYEVPHQAMTLSISDMTCASCVARVERALKAVPGVVEAQV
NLATEQAEVTVLRGAVDAEALAAAVARAGYGAVPVTGELPAGAVPGEGFWSGPWPVAISA
VLSLPLVAPMVAEWFGVHWMLPAWVQWLLATPVQFVFGWRFYKAGFKAVRAGAGNMDLLV
ALGTSAAYGLSLWLMWRGAHDMPHLYFESAAVVITLVRLGKWLETRAKRQTADAIRALAA
LRPDSAIVRRDGAEVSVALGSVRVGDEIVVLPGARVPVDAKVIEGSSHADESMLTGESLP
VPKAPGALLTGGAINYEGRLVARTVAVGAETVLARIIRMVEHAQAAKAPIQRMVDRVSSV
FVPVVLGIALVTLLGWGLFGGNWEAALLNAVAVLVIACPCALGLATPTAIMAGTGAGARA
GILIKDAEALEVAHRVKVVVFDKTGTLTVGKPEVVALAVPAGAGDDAQPRLLAHLAALQA
GSEHPLAHAVLAAARARGIHAPTATDVRALPGMGLSGMVDGVALQLGSERLRASLGAAAG
TLEAQAQALQQAGRTVSWLIEMGAGDASPAQHRVVGLVAFGDAIKPGARRAIERLRAAGV
RTVMLSGDNQGAAARVAKTLGLDEVQAEVLPADKAERVNGLKADGTAVAMVGDGINDAPA
LAAADVGIAMSTGTDVAMHAAGITLMRGDPALVADALAISHRTVRKIRENLFWAFFYNVI
GIPLAAAGLLNPVVAGAAMAFSSVSVVGNALLLRRWKPAGEQA