Protein Info for RR42_RS20070 in Cupriavidus basilensis FW507-4G11

Annotation: glycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 973 transmembrane" amino acids 344 to 364 (21 residues), see Phobius details amino acids 778 to 799 (22 residues), see Phobius details PF02347: GDC-P" amino acids 29 to 454 (426 residues), 590.3 bits, see alignment E=4.7e-181 amino acids 462 to 759 (298 residues), 39.8 bits, see alignment E=5.6e-14 TIGR00461: glycine dehydrogenase" amino acids 29 to 964 (936 residues), 1460.8 bits, see alignment E=0 PF00266: Aminotran_5" amino acids 605 to 721 (117 residues), 24 bits, see alignment E=3.6e-09 PF21478: GcvP2_C" amino acids 792 to 913 (122 residues), 199.4 bits, see alignment E=2.9e-63

Best Hits

Swiss-Prot: 67% identical to GCSP1_PSEPK: Glycine dehydrogenase (decarboxylating) 1 (gcvP1) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 65% identity to ajs:Ajs_1936)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YHN9 at UniProt or InterPro

Protein Sequence (973 amino acids)

>RR42_RS20070 glycine dehydrogenase (Cupriavidus basilensis FW507-4G11)
MNAPLPMTAAQVARPTLAELEARDAFASRHIGPDAAEQQHMLKVLGYDNRAALIDAVIPA
AIRRRDGMPLGEFTAPLTEEAALAKLRGLASKNRVLKSFIGQGYYNTLTPGVVLRNIFEN
PAWYTAYTPYQPEISQGRLEAMLNFQQMVTDLTGLDIANASMLDEGTAAAEAMTLLQRVN
KHASTTFYVADDVLPQTLEVVRTRALPLGIEVKVGPAAEAAGAHAFGVLLQYPGVNGDVA
DYRAIADAVHAAGGLVVAAADLLALTLIAAPGEWGADVAVGNSQRFGVPLGFGGPHAGYM
AVKDAFKRSMPGRLVGVTIDAQGNKAYRLALQTREQHIRREKATSNICTAQVLLAVMASM
YAVYHGPQGLKRIAQRVHRLTATLAGGLEQLGYARTNATFFDTLTLETGFNTEALHASAT
ARGINLRHAGATRIGISLDETASREDVVALLEIFAHGKPVPGFDALEAAAQDAFPAGLAR
QSAYLTHPVFNTHHAEHEMLRYLRMLADKDLALDRTMIPLGSCTMKLNATSEMIPVTWPE
FSKIHPFAPLDQTVGYREMIDQLEAMLCAATGYAAVSLQPNAGSQGEYAGLLIIHAYHAS
RGESHRDICLIPSSAHGTNPASAQMAGMKVVVVACDENGNVDLEDLAKKAEQHSKNLAAI
MITYPSTHGVFEQGVQQICHIVHKHGGQVYVDGANMNAMVGTAAPGQFGGDVSHLNLHKT
FCIPHGGGGPGVGPVAVGAHLADFLPNQDSVGYRRDDQGIGGVSAAPFGSASILPISWMY
IAMMGSAGLTAATENAILAANYVARRLSPHFPVLYTGQHGLVAHECILDVRALQKTTGIS
NEDVAKRLMDYGFHAPTMSFPVPGTLMIEPTESEALHELDRFIDAMIAIRAEIARVEDGT
FDREDNPLKNAPHTAAVITADVWEHKYTRQEAAYPVAALRTQKYWPPVGRADNVYGDRNL
FCACVPMSEYTEE