Protein Info for RR42_RS19790 in Cupriavidus basilensis FW507-4G11

Annotation: C4-dicarboxylate ABC transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 473 transmembrane" amino acids 28 to 47 (20 residues), see Phobius details amino acids 66 to 84 (19 residues), see Phobius details amino acids 96 to 118 (23 residues), see Phobius details amino acids 166 to 189 (24 residues), see Phobius details amino acids 210 to 231 (22 residues), see Phobius details amino acids 242 to 267 (26 residues), see Phobius details amino acids 311 to 340 (30 residues), see Phobius details amino acids 343 to 361 (19 residues), see Phobius details amino acids 372 to 395 (24 residues), see Phobius details amino acids 400 to 423 (24 residues), see Phobius details PF00375: SDF" amino acids 28 to 423 (396 residues), 349 bits, see alignment E=1.8e-108

Best Hits

Swiss-Prot: 78% identical to DCTA2_RALSO: C4-dicarboxylate transport protein 2 (dctA2) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K11103, aerobic C4-dicarboxylate transport protein (inferred from 85% identity to rme:Rmet_3444)

MetaCyc: 54% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"sodium:dicarboxylate symporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YL57 at UniProt or InterPro

Protein Sequence (473 amino acids)

>RR42_RS19790 C4-dicarboxylate ABC transporter (Cupriavidus basilensis FW507-4G11)
MHPAVQQRPASGRPHAAPSRFSRFFRSLFGQVLVALVLGTALGLLFPEFAAKLKPLGDAF
IKLIKMLIGPIVFCVVVAGICGAGELKKVGRVGIKAVLYFEVVTTIALALGIALAYIFHP
GTGMNVNPASLDASAMSAYVDTAQKVKSAGMVDFLLKLIPSTVMGAFASGDVLQVLLVSI
LFGCALSLVGERGQPLVTIIDTFSHTLFKMMGFIIKLAPLGVLGAVAFTVGKYGIGSLKQ
LGYLVLVFYGAVALFVMVVLGTVMRLCGFSVFKLIRYLRAELLVVLGTASSDSVLPQVMK
KLEFLGIKKSVVGLVIPTGYSFNLDAFSIYLTLAAVFIAQATNTPLALGDLLGILAVALV
TSKGAHGIPGSAIVILAATLSAHPAIPAIGLVLVLSVDWFIGIARAVGNLIGNCVATVVV
AAWEKDIDRARAHDVLNGRIDASDLEAGFAPAPHEAALATPGASPLPGAAAGR