Protein Info for RR42_RS18560 in Cupriavidus basilensis FW507-4G11

Annotation: multidrug transporter MatE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 transmembrane" amino acids 37 to 57 (21 residues), see Phobius details amino acids 70 to 100 (31 residues), see Phobius details amino acids 114 to 136 (23 residues), see Phobius details amino acids 156 to 175 (20 residues), see Phobius details amino acids 186 to 206 (21 residues), see Phobius details amino acids 212 to 236 (25 residues), see Phobius details amino acids 257 to 279 (23 residues), see Phobius details amino acids 302 to 323 (22 residues), see Phobius details amino acids 335 to 357 (23 residues), see Phobius details amino acids 377 to 397 (21 residues), see Phobius details amino acids 406 to 426 (21 residues), see Phobius details amino acids 437 to 455 (19 residues), see Phobius details PF01554: MatE" amino acids 43 to 197 (155 residues), 39 bits, see alignment E=3.3e-14 amino acids 273 to 417 (145 residues), 63.9 bits, see alignment E=7.5e-22

Best Hits

KEGG orthology group: None (inferred from 82% identity to reu:Reut_A3060)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YKJ2 at UniProt or InterPro

Protein Sequence (465 amino acids)

>RR42_RS18560 multidrug transporter MatE (Cupriavidus basilensis FW507-4G11)
MNEPQANPMAAAAIAPATAAPIATPTHPLMRELMRRILQLAAPTSLIAFLQAGAQLIETW
LAARQGTAALAGWAVVLPFALLLQQMSTGAMGGGVVAAIARALGANKREEASSLVLHALI
IALTAGLAFAVAMAGFPRAVLGAVAGQTAADAAATYAIWLFGGGAVPAWLANTLASVLRG
GGRHALAARVLSLMWIVFPVLAWTLAEPAGMGLAGIGASLAAVSWAAALAMAWVVLRGGA
GFVPMLRIRPSRALFKRILSVGLVACALASVANLSTILVTTELRHYGTAAVAAYGISARL
EFLMIPLAFGVGSALTALVGRAVGAGDWATARRTAWAGALMALAVAGAVGAVVGLAPDAF
AGFFTKDAEVASIAARALSWVAPAFGGFGLGMALYFASMGAGRMGWPIAAGISRIALAAG
GGWLLANVAGMGLDGHFLGVALGITAYGVVTAFGVRGANWSARGA