Protein Info for RR42_RS18340 in Cupriavidus basilensis FW507-4G11

Annotation: membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 836 transmembrane" amino acids 21 to 49 (29 residues), see Phobius details amino acids 67 to 86 (20 residues), see Phobius details amino acids 91 to 110 (20 residues), see Phobius details amino acids 141 to 161 (21 residues), see Phobius details amino acids 386 to 404 (19 residues), see Phobius details amino acids 409 to 428 (20 residues), see Phobius details amino acids 437 to 454 (18 residues), see Phobius details amino acids 459 to 478 (20 residues), see Phobius details amino acids 484 to 504 (21 residues), see Phobius details amino acids 511 to 531 (21 residues), see Phobius details PF12805: FUSC-like" amino acids 68 to 334 (267 residues), 217 bits, see alignment E=3.1e-68 PF13515: FUSC_2" amino acids 402 to 523 (122 residues), 74.4 bits, see alignment E=9.2e-25

Best Hits

KEGG orthology group: None (inferred from 84% identity to reu:Reut_A3032)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YKD8 at UniProt or InterPro

Protein Sequence (836 amino acids)

>RR42_RS18340 membrane protein (Cupriavidus basilensis FW507-4G11)
MQYAHDARTFVYSHYVYRGLRSATGVIGATLIALQFADLPTAMVVSMGALCTSLMDLPSP
FNHKFNEMLASVLLCTAVTLLVAMATPFPRVMPLVLVLVTFMAGMMTAYGNKTLPLQFSA
LFVMTLTINEDFVVRRALEHSLLFGIGAVAYMAYAMAVSWATQRRTKQQVLAESLYEMAG
YLEIKAGFYDAGSDYEVLFNQLVRQQIVVAERQQAARDLVLRGNRTTHDGLLVQVHMRML
DLYEYILSTNTDYPLLRQTFGSTPVLDHLRRLVQLMCKDVEGIAYDITRGRPSYASVDYR
EELRAVAHEIAQLRYHHINPAAMTAAAETLDMIKGAIVLVEQLHEASRTPVEPSKVLPGP
DMTPFLTRQRYELKVLRDNLNWKSPAFRFALRITMAVGAGLWIAEHLPYVSHSYWILLTI
IVILKPNFSMTKQRYNDRLIGTLIGCVIAVGVLKVVHQPLILLGVLFLALVAGTAFSTIK
YRYTAVAACVQVLIQINLLVPGSATVAGERLIDTVIGGVIATVFSFVLPSWEYRALPALV
ENVLQANRRYIAATRDLLLRVAKDDFAYRVQRKQFMDSLSALIGSFQRMLDEPKSRHRAV
DNLNRFIVQNYLVAAHVAAARIQVREHYGELDLPAAEAAIRQATDAAANSLQLASERLAE
DDRAGGRGAGFIRTVKDPAKAKAPVKAAETAGLVNDRVGANVAVAVGVVHGAADGAAHGA
GGADVAAVSDAQAVRAADAAIATEALTAQPAAEDASERRARLADSADRRRADVLVQAAAS
GELSRAASEAGSIVSTASSTGRTANAILERRLRALREDTAKIALRTGAIGRAMRER