Protein Info for RR42_RS17395 in Cupriavidus basilensis FW507-4G11

Annotation: S-adenosylmethionine tRNA ribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 TIGR00113: S-adenosylmethionine:tRNA ribosyltransferase-isomerase" amino acids 3 to 342 (340 residues), 420.1 bits, see alignment E=3e-130 PF02547: Queuosine_synth" amino acids 4 to 342 (339 residues), 425.7 bits, see alignment E=5.7e-132

Best Hits

Swiss-Prot: 86% identical to QUEA_CUPTR: S-adenosylmethionine:tRNA ribosyltransferase-isomerase (queA) from Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

KEGG orthology group: K07568, S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC: 5.-.-.-] (inferred from 86% identity to cti:RALTA_A2587)

Predicted SEED Role

"S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 5.-.-.-)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.-.-.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 5.-.-.-

Use Curated BLAST to search for 5.-.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y658 at UniProt or InterPro

Protein Sequence (350 amino acids)

>RR42_RS17395 S-adenosylmethionine tRNA ribosyltransferase (Cupriavidus basilensis FW507-4G11)
MLTLSDFDFTLPPELIAQTALPERGASRLLVVDTDAPGGTTRLADRAFTDIVDYLRPNDL
LVFNDTRVIKARFFGQKGSGGKVEVLVERVLDSHTVLAQVRASKTPPVGSLLRLADAFDV
TVGPRVDQFFTLTFPEPALDLIERHGRLPLPPYITHDPDAFDETRYQTVYARAPGAVAAP
TAGLHFDEALFARLDALGVRRGFLTLHVGAGTFQPVRTENLAEHKMHAEWYEVSDALAQA
VRETRAAGGRVIAVGTTSLRALESAGATDGTLAAGRGDTEIFITPGYRFRVVDALITNFH
LPKSTLLMLVSALAGVEPIRAAYRHAVAERYRFFSYGDAMLLTRQPQPQP