Protein Info for RR42_RS17220 in Cupriavidus basilensis FW507-4G11

Annotation: phosphoribosylaminoimidazole synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 94% identical to PUR5_CUPTR: Phosphoribosylformylglycinamidine cyclo-ligase (purM) from Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

KEGG orthology group: K01933, phosphoribosylformylglycinamidine cyclo-ligase [EC: 6.3.3.1] (inferred from 93% identity to rme:Rmet_2911)

MetaCyc: 60% identical to phosphoribosylformylglycinamide cyclo-ligase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylformylglycinamidine cyclo-ligase. [EC: 6.3.3.1]

Predicted SEED Role

"Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)" in subsystem De Novo Purine Biosynthesis (EC 6.3.3.1)

MetaCyc Pathways

superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)

KEGG Metabolic Maps

Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YDL1 at UniProt or InterPro

Protein Sequence (350 amino acids)

>RR42_RS17220 phosphoribosylaminoimidazole synthetase (Cupriavidus basilensis FW507-4G11)
MSASPTSGQAGLSYRDAGVDIDAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKY
KEPVLVSGTDGVGTKLKLAFQLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLD
VETAATVIKGIAHGCELSGCALIGGETAEMPSMYPDGEYDLAGFAVGAVEKSRIIDGTTI
VPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLNGDFHGQRLQDAIMAPTRIYVKPLLSL
IETLPVKGMAHITGGGLTENVPRVLAQNVTAVLQRDAWALPPLFQWLQTQGNVADDEMHR
VFNCGIGMVVIVAKEDADRAIRHLQAAGEAVWQIGEIREREEGQAQTIVA