Protein Info for RR42_RS16900 in Cupriavidus basilensis FW507-4G11

Annotation: N-formimino-L-glutamate deiminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details TIGR02022: formiminoglutamate deiminase" amino acids 6 to 463 (458 residues), 582.4 bits, see alignment E=3.2e-179 PF01979: Amidohydro_1" amino acids 51 to 408 (358 residues), 98 bits, see alignment E=3.5e-32

Best Hits

KEGG orthology group: K05603, formimidoylglutamate deiminase [EC: 3.5.3.13] (inferred from 81% identity to reu:Reut_A2712)

MetaCyc: 53% identical to formiminoglutamate deiminase subunit (Pseudomonas fluorescens)
Formimidoylglutamate deiminase. [EC: 3.5.3.13]

Predicted SEED Role

"Formiminoglutamic iminohydrolase (EC 3.5.3.13)" in subsystem Histidine Degradation (EC 3.5.3.13)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YJD8 at UniProt or InterPro

Protein Sequence (466 amino acids)

>RR42_RS16900 N-formimino-L-glutamate deiminase (Cupriavidus basilensis FW507-4G11)
MNAGSLFATQALLPTGWASDVLLAWDDAGAFTTVQAGAQPAVDVPRAAGPLLPGMPNLHS
HAFQRGFAGLTEFRSETLADGQQSDSFWSWRKLMYRFALRLSPDTLEAIATQLYIEMLRA
GYTSVCEFHYVHHDTHGKPYADPAEMSLRLLRAAQTAGIGITLLPVLYQTAGFGDKPAVP
DQRRFLHETHAMLALLGRLAPQCHGQARLGLAPHSLRAVPPQSLADAVAGLHALDATAPV
HIHIAEQQREVDECITLTGTRPVAWLLDHAEVDARWCLVHATHLDWDERRRLAHSGAVAG
ICPTTEANLGDGVFDAAPYLGQGGVWGIGSDSHASVSVVEELRLFEYGQRLALQKRNVLA
SDAHRQVADRLYLDAAFGGARASGRDIGAIAVGQQADFVVLDGAHPALSGLSGSQALAVH
VFANHGHETLAEVRTAGRMRVQHGLHALQADAGKRFAAARASLLTD