Protein Info for RR42_RS16495 in Cupriavidus basilensis FW507-4G11

Annotation: branched-chain amino acid aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: None (inferred from 76% identity to sro:Sros_5090)

Predicted SEED Role

"Aminodeoxychorismate lyase (EC 4.1.3.38) / Branched-chain amino acid aminotransferase" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 4.1.3.38)

MetaCyc Pathways

superpathway of chorismate metabolism (45/59 steps found)
superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
4-aminobenzoate biosynthesis I (2/2 steps found)
4-aminobenzoate biosynthesis II (1/2 steps found)
superpathway of candicidin biosynthesis (4/11 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.1.3.38

Use Curated BLAST to search for 4.1.3.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YFJ1 at UniProt or InterPro

Protein Sequence (273 amino acids)

>RR42_RS16495 branched-chain amino acid aminotransferase (Cupriavidus basilensis FW507-4G11)
MSASQSSFIVHRNGLPATLAGLAPLAFAGYAHFTAMQVRGGRARGLDLHLERLRVASMAL
FGRALPDDQVRAYLRAALACAPADVSLVATVYSPAGEFTVAGADVEPEMLVRTGPPASGP
QGPLGLAAVPHERVLPALKHVGEVAKTYFLRQSVGKGFDDAAFVDARGRLSEGTIWNLVF
WDADAETVVWPEAEMLAGTTMGIVRRQLDRLGVRQRVQPVALADLPGLGGAAVMNSWTPG
VAVNRIGSAPMPAAPSFVALLHRAYQMEEPVSP