Protein Info for RR42_RS16225 in Cupriavidus basilensis FW507-4G11

Annotation: cytosol aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 522 PF02789: Peptidase_M17_N" amino acids 27 to 134 (108 residues), 78.4 bits, see alignment E=4.7e-26 PF00883: Peptidase_M17" amino acids 213 to 513 (301 residues), 431.6 bits, see alignment E=1.8e-133

Best Hits

Swiss-Prot: 88% identical to AMPA_CUPNH: Probable cytosol aminopeptidase (pepA) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 88% identity to reh:H16_A2990)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YFF4 at UniProt or InterPro

Protein Sequence (522 amino acids)

>RR42_RS16225 cytosol aminopeptidase (Cupriavidus basilensis FW507-4G11)
MEFSTKALDWIKAGQNGFLATKTDCLVVGLFEGQSLAGVAKALDVATKGLVSRLIKLGDF
EGKRGTQLMLHEVAGVGAARILLVGFGKEAEFGDKAFAEAVRTALRALSGTRAANVLWCL
AQQQAPQQAGNARDLGWRLITTVTLIREAGYRLLERHPGLKRANANAKGDGNGNGADKLT
GLRKVVLTVDAADAKAAAQAVVRGAAIANGMELTKDLGNLPSNICTPTYLANTARGIAKR
HKLKVEVLGRKQLEALKMGAFLAVTKGAVEPPQFIVLRYDGASAKQAPVVLVGKGITFDT
GGISLKPGEGMDEMKYDMCGAASVLGTLQAVAEMGLKLNVIAVVPTCENMPSGNATKPGD
VVTSMSGQTIEILNTDAEGRLVLCDALTYVERFKPAAVVDVATLTGACIIALGHVNSGLY
ARNDGLADQLLQAGRKAMDTAWRMPLDDDYQDQLKSNFADMANIGGRPAGSVTAACFLAR
YTEKYDWAHLDIAGTAWKSGAAKGATGRPVPLLAQFLMDRAG