Protein Info for RR42_RS16125 in Cupriavidus basilensis FW507-4G11
Annotation: Cob(I)yrinic acid a,c-diamide adenosyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 70% identical to COBO_PSEAE: Corrinoid adenosyltransferase (cobO) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG orthology group: K00798, cob(I)alamin adenosyltransferase [EC: 2.5.1.17] (inferred from 88% identity to cti:RALTA_A2443)MetaCyc: 54% identical to CobO (Pseudomonas denitrificans (nom. rej.))
Cob(I)yrinic acid a,c-diamide adenosyltransferase. [EC: 2.5.1.17]
Predicted SEED Role
"Cob(I)alamin adenosyltransferase (EC 2.5.1.17)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 2.5.1.17)
MetaCyc Pathways
- superpathway of adenosylcobalamin salvage from cobinamide I (8/8 steps found)
- adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide (6/6 steps found)
- superpathway of adenosylcobalamin salvage from cobinamide II (8/9 steps found)
- adenosylcobalamin salvage from cobalamin (5/5 steps found)
- adenosylcobinamide-GDP salvage from cobinamide I (5/5 steps found)
- adenosylcobinamide-GDP salvage from cobinamide II (5/6 steps found)
- adenosylcobalamin biosynthesis II (aerobic) (24/33 steps found)
- cobalamin salvage (eukaryotic) (4/8 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (22/36 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.5.1.17
Use Curated BLAST to search for 2.5.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4YCQ4 at UniProt or InterPro
Protein Sequence (213 amino acids)
>RR42_RS16125 Cob(I)yrinic acid a,c-diamide adenosyltransferase (Cupriavidus basilensis FW507-4G11) MTEPKAIETSTSEDAARDERHKARMLRKKDVVDAKIAAAQDERGVIVITTGNGKGKSSSG FGMVVRALGHGMQAGVVQFIKGAIPSGEELFLRRFPEQCAFHVMGEGYTWETQDRARDVA KAQAAWEVARSLLRDPSIGLVLLDELNIALKLHYLDVDTVIADLRARPPMQHVVITGRGA PPALIEAADTVTDMTPVKHAFQQGIKAQRGVEM