Protein Info for RR42_RS15980 in Cupriavidus basilensis FW507-4G11

Annotation: formate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1007 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 45 to 74 (30 residues), 16.9 bits, see alignment (E = 3.2e-07) PF04879: Molybdop_Fe4S4" amino acids 92 to 141 (50 residues), 36.7 bits, see alignment 5e-13 PF00384: Molybdopterin" amino acids 147 to 602 (456 residues), 153.1 bits, see alignment E=1.6e-48 PF01568: Molydop_binding" amino acids 873 to 999 (127 residues), 64.5 bits, see alignment E=1.3e-21

Best Hits

KEGG orthology group: K00123, formate dehydrogenase, alpha subunit [EC: 1.2.1.2] (inferred from 76% identity to bbr:BB2121)

Predicted SEED Role

"Formate dehydrogenase-O, major subunit (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YF88 at UniProt or InterPro

Protein Sequence (1007 amino acids)

>RR42_RS15980 formate dehydrogenase (Cupriavidus basilensis FW507-4G11)
MILTRKRAAQGSASSQLAGGSGERAGGRLSERLAAGLAGAMPTMDRRSFLKRSGIGVGAG
LAASQLTLLRRADAADASGAAAGGEDKGNIVVRRTVCGHCSVGCAVDAVVHNGVWVRQNP
VFDSPINMGAHCAKGAALREHGHGEYRLKYPMKLVNGKYQRIGWDQALDEITARMKEIRQ
QTGPDSMFFVGSSKHSNEGSYLLRKWVSFFGTNNTDHQARICHSTTVAGVANTWGYGAMT
NSYNDMQNARAALYIGSNAAEAHPVSMLHLLHAKENGCKVIVVDPRYTRTAAKSDHYVRV
RSGTDIAFLFGVLYHIFQNGWEDQKYINDRVYGMDKVKAEVLAKWTPDKVEEVCGVPEAQ
VRQVAEIMAKNRPSTLVWCMGQTQHTIGNAIVRASCLVQLALGNIGVSGGGANIFRGHDN
VQGATDVGPNPDSLPGYYGLATGAWKHFAAVWGVDYEWIKKQYASQAMMEKSGTTVSRWI
DIVTEKPELIDQDNNVRGVFFWGHAPNSQTRGLEMKKALDKLDLLVVIDPYPSATAAMAN
MPPAEGDKVNPNRAVYLLPACTQFETTGSCTASNRSLQWREKVIEPLFESMPDHTIMQAF
ADRLGFGKELSKNFKLNEVKRAGRTWMEPEVESILREINASNWTIGYTGQSPERLKSHMR
NMEKFDVRTLRCLGGKDPLTGYDLTGDYFGLPWPCYGTPELKHPGSPNLYDTSRNVMDGG
GNFRANFGVERDGVSLLAEDGSYSKGADITTGYPEFDHVLLKKLGWWDELTDAEKQKAEG
KNWKTDLSGGIQRVVLKNHGCHPFGNAKARAVVWNFPDPIPQHREPLYSTRPDMVAKYPT
HDDKMAFWRLPTLYKSLQQRNVENKLYEKFPIILTSGRLVEYEGGGEETRSNPWLAELQQ
ENFVEINPRAASDRGIRNGDYCWVSTPTGAHIKVRALVTERVGVDTAFIPFHFSGWWQGK
DLKDYYPEGAMPIVRGEAINTATTYGYDSVTMMQETKTTICQIARFT