Protein Info for RR42_RS15965 in Cupriavidus basilensis FW507-4G11

Annotation: formate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01583: formate dehydrogenase, gamma subunit
  • amino acids 174 to 376 (203 residues), 166.7 bits, E=3.4e-53
• PF01292: Ni_hydr_CYTB
  • amino acids 176 to 354 (179 residues), 79.2 bits, E=1.7e-26

Best Hits

KEGG orthology group: K00127, formate dehydrogenase, gamma subunit [EC: 1.2.1.2] (inferred from 79% identity to reu:Reut_A0685)

Predicted SEED Role

"Formate dehydrogenase O gamma subunit (EC 1.2.1.2)" in subsystem Formate dehydrogenase or Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

See A0A0C4YIW5 at UniProt or InterPro

Protein Sequence (403 amino acids)

>RR42_RS15965 formate dehydrogenase (Cupriavidus basilensis FW507-4G11)
MKPTLNPGWFRYLAGVACALALLAPPGAARAQAQAPAQSASAPQAAGVPAEANNPATHPA
QPFAGIASENIFNVPRRDIAAEAQAQQARSKEQPGNNAPVWREANSDQAHYSSLPAKEAG
VLIQRTGQKWRLLRNGVITVWGGWLIVVVPAAILAFFFWRGTIPLKTLRTGRMIQRFTPL
ERMVHWTMAISFVTLAVSGIVMLFGKHFLLPLMGHTLFGWLTYLLKNVHNIVGPVFTLSV
IVGFVIFVRDNFPAREDWQWLIKLGGLVSGKHVPSGRFNAGEKAWFWGGLVVFGLILSAS
GWVLDMIVPGMDFYRATMQVANVIHGIAAVLMIAMACGHIYMGTIGMEGAYRAMRDGWVD
EAWAKEHHELWYDDIKAGKIAAQRAAEPEPGERAGGRASPGEV