Protein Info for RR42_RS15775 in Cupriavidus basilensis FW507-4G11

Annotation: N-acetylneuraminate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 349 TIGR03586: pseudaminic acid synthase" amino acids 16 to 343 (328 residues), 497.3 bits, see alignment E=9.9e-154 PF03102: NeuB" amino acids 36 to 275 (240 residues), 287.5 bits, see alignment E=8.3e-90 PF08666: SAF" amino acids 291 to 348 (58 residues), 49.9 bits, see alignment E=3.8e-17

Best Hits

KEGG orthology group: K01654, N-acetylneuraminate synthase [EC: 2.5.1.56] (inferred from 92% identity to rpf:Rpic12D_0587)

Predicted SEED Role

"N-acetylneuraminate synthase (EC 2.5.1.56)" in subsystem CMP-N-acetylneuraminate Biosynthesis or Sialic Acid Metabolism (EC 2.5.1.56)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.56

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y5C3 at UniProt or InterPro

Protein Sequence (349 amino acids)

>RR42_RS15775 N-acetylneuraminate synthase (Cupriavidus basilensis FW507-4G11)
MTINIGGRLVGREHEPFLIAEMSGNHNQSLDRALEIVDAAAASGAHALKIQTYTADTMTL
DIREREFFISDPKSLWKGKSLYELYDEAHTPWDWHAAIFERARGHGMIPFSTPFDDSAVD
FLEGLDVAVYKIASFENTDIPLIRKVARTGKPMIISIGMASIAELDQSVRAAREAGCKDL
ILLKCTSTYPASPENTNVRTIPHMRDLFGCEVGLSDHTMGLGVSVASVAMGATVIEKHFT
LDRADGGVDSSFSLEPAEFQALVVETRRAWQGLGGVSYGPTDAEKKSLVFRRSLYITRDL
KAGEVLDASSVRAIRPGFGLAPKHLDQVLGRAVKQDVSRGTPLEWDLLA