Protein Info for RR42_RS15115 in Cupriavidus basilensis FW507-4G11

Annotation: threonine aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01212: Beta_elim_lyase
  • amino acids 4 to 293 (290 residues), 253.8 bits, E=2.2e-79
• PF00266: Aminotran_5
  • amino acids 39 to 234 (196 residues), 25.3 bits, E=7.7e-10

Best Hits

Swiss-Prot: 65% identical to LTAE_PSEUN: Low specificity L-threonine aldolase (ltaE) from Pseudomonas sp. (strain NCIMB 10558)

KEGG orthology group: K01620, threonine aldolase [EC: 4.1.2.5] (inferred from 96% identity to reu:Reut_A0859)

Predicted SEED Role

"Low-specificity L-threonine aldolase (EC 4.1.2.48)" (EC 4.1.2.48)

MetaCyc Pathways

• superpathway of L-threonine metabolism (15/18 steps found)
• L-threonine degradation IV (2/2 steps found)
• glycine biosynthesis IV (1/1 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.48 or 4.1.2.5

Sequence Analysis Tools

See A0A0C4YC52 at UniProt or InterPro

Protein Sequence (343 amino acids)

>RR42_RS15115 threonine aldolase (Cupriavidus basilensis FW507-4G11)
MQHFASDNYAGFCPESLKYFLEANGSGHEQAYGDDSWTQKVCDRIRDLFQTDCEVFFVFN
GTAANSLALSALCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGANGKLTPDAVE
ALVTRRSDIHYPKPKVVSLTQSTEVGTVYTVEEVRAIAAIAKRRQLRVHMDGARFANAVA
SLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRKLAEDFAYRVKQAGQLASKMRF
ISAPWLGLLENDVWLGNARHANAMAQLLHERIASIPGVRIMFPTESNAVFAELPLAAIEA
LRAKGWRFYTFIGAGGCRFMCSWDLQPETVEALAADMRVACGA