Protein Info for RR42_RS14645 in Cupriavidus basilensis FW507-4G11
Annotation: urocanate hydratase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 91% identical to HUTU_PSEA7: Urocanate hydratase (hutU) from Pseudomonas aeruginosa (strain PA7)
KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 91% identity to pap:PSPA7_5833)MetaCyc: 91% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]
Predicted SEED Role
"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)
MetaCyc Pathways
- L-histidine degradation II (5/5 steps found)
- L-histidine degradation VI (7/8 steps found)
- L-histidine degradation I (4/4 steps found)
- L-histidine degradation III (4/6 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.49
Use Curated BLAST to search for 4.2.1.49
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4YHZ5 at UniProt or InterPro
Protein Sequence (561 amino acids)
>RR42_RS14645 urocanate hydratase (Cupriavidus basilensis FW507-4G11) MSNTDRFRDVEIRAPRGNQLNAKSWQTEAPLRMLMNNLDPEVAENPKELVVYGGIGRAAR NWACYDKIVETLKTLNDDETLLVQSGKPVGVFKTHGNAPRVLIANSNLVPHWATWEHFNE LDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYNGNLKGRWVLTAGLGGMGG AQPLAATLAGACSLNIECQQASIDFRLRTRYVDEQATDLDDALARIARYTAEGRAVSIAL CANAAEVLPELVRRGVRPDMVTDQTSAHDPLNGYLPVGWTWGQYRDRAQTEPARVVKAAK QSMALHVQAMLDFQKLGVPTFDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGVGP FRWAALSGDPQDIYKTDAKVKELIPDDAHLHRWLDMARERISFQGLPARICWVGLGLRAK LGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETESMQDGSDAVSDWPLLNALLNTA SGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDEAAARIARVLHNDPATGVMRHADAGYDI AIDCAREQGLNLPMLNSKKEA