Protein Info for RR42_RS13555 in Cupriavidus basilensis FW507-4G11

Updated annotation (from data): anthraniloyl-CoA monooxygenase (EC 1.14.13.40)
Rationale: Specifically important for: L-Tryptophan. Antrhanioyl-CoA is a synonym for 2-aminobenzoyl-CoA, an intermediate in the degradation of Trp via 2-aminobenzoate (KEGG_correct)
Original annotation: salicylyl-CoA 5-hydroxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 796 PF01494: FAD_binding_3" amino acids 2 to 149 (148 residues), 24.2 bits, see alignment E=1.9e-09 PF00724: Oxidored_FMN" amino acids 422 to 751 (330 residues), 226.4 bits, see alignment E=6.4e-71

Best Hits

KEGG orthology group: K09461, anthraniloyl-CoA monooxygenase [EC: 1.14.13.40] (inferred from 78% identity to bpt:Bpet0549)

Predicted SEED Role

"probable bifunctional hydroxylase/oxidoreductase"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.13.40

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YHI0 at UniProt or InterPro

Protein Sequence (796 amino acids)

>RR42_RS13555 anthraniloyl-CoA monooxygenase (EC 1.14.13.40) (Cupriavidus basilensis FW507-4G11)
MRVLCIGGGPSGLYFGLLMKLRDPSSEVYVVERNRPYDTFGWGVVFSDATMDNLKQADPV
SAEQINAAFNHWDDIDIHIGGRTLRSGGHGFIGIGRKRLLNILQARCEALGVHLVFETDV
TDDQALAQQYQADIVIASDGINSRVRGRYAETFQPDIDTRLCRFVWLGTRKLFDAFTFAF
EKTEHGWFQAHAYRFDDNTSTFIVEAPEPVWRAAGIEQMSQEEGVAFCERLFARYLDGNA
LISNATHLRGSANWIRFPRVICGTWVHWNTLAGGRRVPVVLMGDAAHTAHFSIGSGTKLA
LEDAIDLANNIRDAGPGGADVLPQALERYQATRSVEVLKIQNAARNSTEWFENVERYAGL
APEQFAYSLLTRSQRISHENLRVRDPGYVEGFERWLAGQAAANVANATSTGQAAEARVVP
PMFTPLRVRNVTLKNRVVVSPMAMYSCEDGVPGDFHLTHLGARALGGAGMVVAEMTCTSP
DARITPGCPGLWNDEQRDAWRRIVDFVHANSDARIAMQIGHAGRKGSTQLGWEQMDYPLA
EGNWPVLSASPLPYMPGISQVPREMSRADMDAVRDDFVASARRAAQAGFDWLELHCAHGY
LLSSFISPLTNQRSDEYGGSLQARLRYPLEVFAAVRAVWPQERPMSVRISAHDWVEGGIT
PDDAIEIARAFKAAGADMIDCSSGQVSPDQAPVYGRMYQTPFADRIRNEAGIATIAVGAI
FEADHVDSIIAAGRADLCAIARPHLADPAWTIHEAARLGHRDLAWPKQYQAGKRQLETNL
ERAAQQARQARQPEDH