Protein Info for RR42_RS13435 in Cupriavidus basilensis FW507-4G11

Annotation: polyphosphate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 694 TIGR03705: polyphosphate kinase 1" amino acids 9 to 688 (680 residues), 945.7 bits, see alignment E=7.6e-289 PF13089: PP_kinase_N" amino acids 10 to 114 (105 residues), 113.2 bits, see alignment E=1.8e-36 PF02503: PP_kinase" amino acids 124 to 306 (183 residues), 193.4 bits, see alignment E=7.7e-61 PF17941: PP_kinase_C_1" amino acids 333 to 503 (171 residues), 241.7 bits, see alignment E=7.9e-76 PF13090: PP_kinase_C" amino acids 514 to 684 (171 residues), 215.2 bits, see alignment E=1.1e-67

Best Hits

Swiss-Prot: 71% identical to PPK1_BURVG: Polyphosphate kinase (ppk) from Burkholderia vietnamiensis (strain G4 / LMG 22486)

KEGG orthology group: K00937, polyphosphate kinase [EC: 2.7.4.1] (inferred from 88% identity to reu:Reut_A2160)

Predicted SEED Role

"Polyphosphate kinase (EC 2.7.4.1)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism or Purine conversions (EC 2.7.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.1

Use Curated BLAST to search for 2.7.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y473 at UniProt or InterPro

Protein Sequence (694 amino acids)

>RR42_RS13435 polyphosphate kinase (Cupriavidus basilensis FW507-4G11)
MSTSPPGTLLNREMGILEFNTRVMAQAADASVPLLERLKFICIVSSNLDEFFEIRMAGLK
EQMRDNPSGITPDGLSLQQAYQIVTERVQKLVTMQYDMLQNVIFPLLEKEGVFFHLASTW
NEAQREWARSFFTRELGPVLTPIALDPAHPFPRVLNKSLNFVIELSGKDAFGREADLAIV
QAPRALPRVVRMPEQLSGYPYGFVLLSSFMQAFVHELFPAIKVNGCYQFRVTRNSDLFVS
EDDITDLREALQGELPTRHFGDTVRLEISSDTPPAMARRLLLESGLGEQDVYRVSGPVNL
VRLMQIPDLVDRPALKYPPHVPAPVKVFAPGASMFDAIRQQDVLLHHPYESFSSVLDLLQ
QAAVDPAVVAIKQTVYRTGNESPVMEALMTAARNGKEVTVVVELLARFDEETNINWAERL
ESAGAHVVYGVVGHKCHAKMLLMVRRELEGAKSKQFKLRRYAHLGTGNYHPRTARLYTDF
GLLTANEKICEDVQHVFQLLTGTAGTIRLNHLWQSPFTMQSNLVEHIRAEARNARAGKPA
RIMAKMNALLEPSIIEELYKASRAGVKIDLIIRGVCALRPGVPGLSEHITVRSIVGRFLE
HHRVYYFLAGGTEVVYLSSADWMDRNLFRRVEVAFPVLDKVLKARVIKESLRVHLHDNAS
AWIMQSDGSYIRKHTKSKQPHVSQNDLLALFGSA