Protein Info for RR42_RS13335 in Cupriavidus basilensis FW507-4G11

Annotation: multidrug transporter MatE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details transmembrane" amino acids 48 to 68 (21 residues), see Phobius details amino acids 88 to 106 (19 residues), see Phobius details amino acids 125 to 144 (20 residues), see Phobius details amino acids 154 to 175 (22 residues), see Phobius details amino acids 187 to 208 (22 residues), see Phobius details amino acids 237 to 260 (24 residues), see Phobius details amino acids 272 to 295 (24 residues), see Phobius details amino acids 313 to 332 (20 residues), see Phobius details amino acids 352 to 374 (23 residues), see Phobius details amino acids 385 to 407 (23 residues), see Phobius details amino acids 419 to 440 (22 residues), see Phobius details PF01554: MatE" amino acids 14 to 173 (160 residues), 98.9 bits, see alignment E=1.3e-32 amino acids 240 to 400 (161 residues), 100.6 bits, see alignment E=3.8e-33 TIGR00797: MATE efflux family protein" amino acids 14 to 421 (408 residues), 241.5 bits, see alignment E=7.4e-76

Best Hits

Swiss-Prot: 44% identical to NORM_AROAE: Probable multidrug resistance protein NorM (norM) from Aromatoleum aromaticum (strain EbN1)

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 83% identity to rme:Rmet_2139)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YB24 at UniProt or InterPro

Protein Sequence (448 amino acids)

>RR42_RS13335 multidrug transporter MatE (Cupriavidus basilensis FW507-4G11)
MFHDIRRISVLAAPVLVGQLAVIAFGVIDTIMAGRASAIDLAAVGLGGSIYITVYISLMG
VLQALAPIAGQLHGAGRAAEIGNEVRQAAWLGLALAIPGMLLLLFPGPLLEFAQAPPELV
EKATHYLHIQAFGLPAALGFRIYSALNNALSRPVMVTVLQLVGLVVKIPLNAWFIDGGFG
LAPMGGPGCALASALISWIWCISGIMILRRNAAYRTLQIFSSWAWPQARPIRALLRLGVP
MGLTYLIEITSFTLMSIFITRMGTVVLAGHQIIANLGAVAYMLPLSLAIATSTLVAQSIG
ARDQDSARRIARHGICLAATLAIMVGGLLWILREPLLHAYAKDPAVVRAALPLMLFIAFY
QAFDAVQVMTAFILRAYKIALVPTLIYAASLWGVGLGGGYVLGFGLIDALPAFTRGAAGF
WLANSISLAIAGSLLVRYFATVSRRRAI