Protein Info for RR42_RS13285 in Cupriavidus basilensis FW507-4G11

Annotation: DNA polymerase III subunit gamma/tau

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 766 TIGR02397: DNA polymerase III, subunit gamma and tau" amino acids 3 to 360 (358 residues), 416.5 bits, see alignment E=5.1e-129 PF13177: DNA_pol3_delta2" amino acids 20 to 183 (164 residues), 132.3 bits, see alignment E=3.5e-42 PF00004: AAA" amino acids 42 to 176 (135 residues), 39.6 bits, see alignment E=1.4e-13 PF12169: DNA_pol3_gamma3" amino acids 237 to 364 (128 residues), 74.8 bits, see alignment E=1.3e-24 PF12170: DNA_pol3_tau_5" amino acids 646 to 761 (116 residues), 29.9 bits, see alignment E=1.1e-10

Best Hits

KEGG orthology group: K02343, DNA polymerase III subunit gamma/tau [EC: 2.7.7.7] (inferred from 75% identity to reh:H16_A2389)

Predicted SEED Role

"DNA polymerase III subunits gamma and tau (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y449 at UniProt or InterPro

Protein Sequence (766 amino acids)

>RR42_RS13285 DNA polymerase III subunit gamma/tau (Cupriavidus basilensis FW507-4G11)
MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
ALNCIGPDGTGDITAQPCGVCKACTEIDSGRFVDYIEMDAASNRGVDEMASLLDKAVYAP
TAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPAHVKFILATTDPQKIPVTVLSRCLQFNL
KQMPPGHIVSHLDHVLGEEGIVREPNALRLLAQAAHGSMRDALSLTDQAIAYSAGQVSEA
AVRGMLGAIDQSYLVQLLDALAAEDGPAMLAVADGMADRSLSFAGALQDLASLLHKIALA
QAVPASVQEEWPEAAEVRRFAAAFDAQEVQLFYQIANLGRSELALAPDEYAGFTMTLLRM
LAFRPSASPTPTVAQGGGQPAPRTRGGAAPAARVAADTAAASAAAAPVAPSLRAAAPMPA
ADPSAAQAQQPAPAAPARTLSPAPAAVAPATAPASAAPMSPARAALAAARLASAARAGGS
PRMPPPAAAPAAPAARPPSAHPLRPPGPPVAVSRPAAPVPAAQATAPARREPVPARQAAS
DARDVRDSGPSDDVPPWEHAGSSDVPPWEDLPPDLPVIGPYDSDPEPMPSRQAALRREPA
PRAAPPAPAPAAVQAAPAEPVAPVRLTPPKPPAAGEDGTPPVFTGAWPALAASLPLKGLA
QQLAYQSELVQVVGRTFHLRAPVAPITEAGVVERLQQTLAEHLGAEVRVQCEIGAVADTA
AAADAQARAERQREAEATIEGDPFVQGLLREFGGTILEGSIQPRAA