Protein Info for RR42_RS13065 in Cupriavidus basilensis FW507-4G11

Annotation: ribonuclease R

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 863 TIGR02063: ribonuclease R" amino acids 9 to 592 (584 residues), 707.8 bits, see alignment E=1.6e-216 TIGR00358: VacB and RNase II family 3'-5' exoribonucleases" amino acids 63 to 744 (682 residues), 708.1 bits, see alignment E=1e-216 PF08206: OB_RNB" amino acids 76 to 133 (58 residues), 78.3 bits, see alignment 5.7e-26 PF17876: CSD2" amino acids 154 to 227 (74 residues), 89.5 bits, see alignment E=2.5e-29 PF00773: RNB" amino acids 249 to 580 (332 residues), 372.8 bits, see alignment E=3.2e-115 PF00575: S1" amino acids 661 to 741 (81 residues), 42.9 bits, see alignment E=1.1e-14

Best Hits

KEGG orthology group: K12573, ribonuclease R [EC: 3.1.-.-] (inferred from 74% identity to bur:Bcep18194_A4688)

Predicted SEED Role

"3'-to-5' exoribonuclease RNase R" in subsystem RNA processing and degradation, bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.1.-.-

Use Curated BLAST to search for 3.1.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YAR7 at UniProt or InterPro

Protein Sequence (863 amino acids)

>RR42_RS13065 ribonuclease R (Cupriavidus basilensis FW507-4G11)
MNQNNYPIPSREEILGVLRTSGSPLSGGDIAKALAVTRKEHDGFQKRLAAMERDGQIELN
RKGRYELANQPNFVVGRVQGHRDGFGFLIRDDGDDDIFLPERELQKAMHNDRAQVRVIGY
DRRGRPEGQIVEILERANRYVIGRLLSEGGVLVVAPEDKRISQDILIPPKSQGKAQVGQV
VSVEIIDYPDRYVQPVGRVVEVLGDFDDPGMEIEIAVRKYGVPHEFSDACAKEAAGLPDE
VRESDLEHRIDLRDVPLVTIDGEDARDFDDAVYCEPVKIGRSKGWRLVVAIADVSHYVRP
GTALDADALDRATSVYFPRRVIPMLPEKLSNGLCSLNPQVDRLCMVCDAVITAKGELKGY
QFYPAVMHSAARLTYNEVWSVLSNTKGPEAHKRADLVPHLQNLYELFQVLLKARRERGAI
DFDTTETYIVCNAQGKIEQILPRTRNDAHRLIEECMLAANVCAADFLERFKHPTLYRIHA
GPGEEKLKNLREFLRTVGLSLAGGDKPQAGDYADVMDKIKSRPDAPMLQTMLLRSMQQAV
YSPDNIGHFGLSYEAYAHFTSPIRRYPDLLTHRAIKAVLAHTKYRPAFAPGTALNTAIAP
KARRMQAKDAAEKAERSAARAQRNEAIWDELGLHCSANERRADEASRDVEAWLKCYFMRD
KLGSEYSGTISSVTSFGIFVQLDELYVEGLVHVTELGSDYFQYDEARNELRGERTGIRYR
LTDRVRVQVSRVDLDARKIDFRLVQEPSAKNLRGRAPTVDAAPRVPAAHAVPARKKGRQL
AALLGGSSKPEESFDETLDRVIEEQPVFEAVMTPVKPHVGHGAKAGGKPAKRAAKPKPQH
LGSTHKGGAKPAGKSSRASRKRT