Protein Info for RR42_RS12720 in Cupriavidus basilensis FW507-4G11

Annotation: hemolysin D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 transmembrane" amino acids 37 to 56 (20 residues), see Phobius details PF00529: CusB_dom_1" amino acids 48 to 416 (369 residues), 26.7 bits, see alignment E=8.9e-10 PF13533: Biotin_lipoyl_2" amino acids 80 to 123 (44 residues), 33.4 bits, see alignment 6e-12 PF13437: HlyD_3" amino acids 317 to 433 (117 residues), 42.9 bits, see alignment E=1.4e-14

Best Hits

KEGG orthology group: K02022, (no description) (inferred from 83% identity to reh:H16_A2686)

Predicted SEED Role

"HlyD family secretion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YGX6 at UniProt or InterPro

Protein Sequence (460 amino acids)

>RR42_RS12720 hemolysin D (Cupriavidus basilensis FW507-4G11)
MKDDSRDNRLKPLSEALEDHSAEGIAILSAEPWKLMQISVLVMVSLVVCALVWSFVGHAD
VIVSADGTLAPESEVRRFYAPVDGELADLYVAEGQPVNKDDVLARLNARGAIEAATNALE
AQLKLQDSEREWKQFPDKKLLMERKAAALKQQIDVAERLHENRTAEGTTRLAEQQRAQLQ
QARSNLDSARRTREFARQEQDRYARLFALPGGGGVSQSQVEGKRIAAVEAENALQIAQSR
LAELDSKLSQEFNQATVQLEGSSQELTNLRIQYDAALREMANTEDKLRLQVQTARLVAEA
AARIRFENIDKDNFLLILAPVAGVITDVSSTQRGDKVLANAPLGGIAPKNARPVLKIEIA
ERDRAFLREGLPVKLKFNAFPYQRYGLIAGTLEYISPATKLAGPNKQPVYEGRVRLAQDY
YTVADNKYPLRYGMTATAEIVVRERRLIDLGLDPFRQVAG