Protein Info for RR42_RS12710 in Cupriavidus basilensis FW507-4G11

Annotation: peptidase C39

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1019 transmembrane" amino acids 126 to 148 (23 residues), see Phobius details amino acids 459 to 481 (23 residues), see Phobius details amino acids 496 to 521 (26 residues), see Phobius details amino acids 570 to 594 (25 residues), see Phobius details amino acids 600 to 618 (19 residues), see Phobius details amino acids 678 to 702 (25 residues), see Phobius details amino acids 715 to 738 (24 residues), see Phobius details PF00027: cNMP_binding" amino acids 40 to 124 (85 residues), 55.4 bits, see alignment E=9.8e-19 amino acids 169 to 256 (88 residues), 58.9 bits, see alignment E=8.2e-20 PF03412: Peptidase_C39" amino acids 306 to 434 (129 residues), 132.8 bits, see alignment E=1.4e-42 PF00664: ABC_membrane" amino acids 463 to 729 (267 residues), 152.6 bits, see alignment E=3.8e-48 PF00005: ABC_tran" amino acids 796 to 945 (150 residues), 117.6 bits, see alignment E=1.4e-37

Best Hits

KEGG orthology group: K06147, ATP-binding cassette, subfamily B, bacterial (inferred from 87% identity to reh:H16_A2684)

Predicted SEED Role

"ABC-type bacteriocin/lantibiotic exporter, contains an N-terminal double-glycine peptidase domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YCU4 at UniProt or InterPro

Protein Sequence (1019 amino acids)

>RR42_RS12710 peptidase C39 (Cupriavidus basilensis FW507-4G11)
MQASPELHPLADFLAGVEILSPFSREEMERLAEHAQALSYGFGETICNAGEAADGLFIIK
SGSVRIFNEDNGKEVSLGVRKAREVFADIAMLREYRHESSVRSSAKTELLFIPRSATEPM
IAQNPAAMAFVASYVAIGSAGGFVARLFDLRGKLDKSELEEAVRSVGVKRVSAGKEILKQ
DAREDRRLYVVRQGEVRIVRTEEGVEYPLATLRQGDIFGERACVMRQEQIASAIAGTDAR
LLVIPEKTVQLILERNPKLREVLEERIRFIDRELHRQKRMAERRKHPVMLDLRSKPEFGE
RVIRRFALVEQAEEMDCGAACLAMICRHHGISMTLGKLRELANVTTQGATLDSLARAGES
LGFTTRGVQCTHDSLLGFELPFIVHWEGYHYVVVYGVSKRWVWVADPALGFRKMGVEEFE
RGWSGTCLLFTSGESMAQLAVARSPWLRFIGYLAPYKRILAHLFMATFVIQVLGVVPPLI
IQNILDGVVVHQNMGLLNLLILGLIVSSVFSQLMSSVRAYLANFMVRNMDFAMMSHFFKH
TLSLPFSFFAKRKTGDIFARFQENQTIRAFLTESTVTTALNLLMVFIYFTIMFLYNVKMT
LVLIAFVIPIAILTIVATPKVKAFAREVFTTTTDARSYLMEALGGVETVKGMGIERPVRL
KWEKKYAKALEVQYRAQAFHILVGLASQLLNAATTIAVLWVGANLVLQRELTVGQLIAFN
AFMGSVLAPLMGLVALWGQLNDAGVAMERLGDVLDLDPEQKPQDLASRVMLPDLQGEINL
DGVYFRYGGAETPYVLENISFSIKPGELLAIVGRSGSGKTTLAKMLVGFYVPTEGKITVD
GYDLGVIDKEYYRAQIGYVMQSNLLFSGTIAENIACGDDSPDRRHIEEVAKMADAHAFIS
KLPLGYEQVVGERGVGLSGGQIQRLCIARALYHDPRLLVFDEATSALDTQSESNILGNMQ
EILQGRTAVIIAHRLSTIMRADKILVLYEGAIVEQGRHEELLERKGMYYQLVQKQLSSE