Protein Info for RR42_RS12615 in Cupriavidus basilensis FW507-4G11

Annotation: LexA family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 218 PF01726: LexA_DNA_bind" amino acids 1 to 65 (65 residues), 98.2 bits, see alignment E=1.9e-32 TIGR00498: repressor LexA" amino acids 1 to 214 (214 residues), 225.7 bits, see alignment E=2.2e-71 PF00717: Peptidase_S24" amino acids 94 to 210 (117 residues), 108.7 bits, see alignment E=1.5e-35

Best Hits

Swiss-Prot: 88% identical to LEXA_CUPMC: LexA repressor (lexA) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: K01356, repressor LexA [EC: 3.4.21.88] (inferred from 91% identity to cti:RALTA_A1825)

Predicted SEED Role

"SOS-response repressor and protease LexA (EC 3.4.21.88)" in subsystem DNA repair, bacterial (EC 3.4.21.88)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.88

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YAG8 at UniProt or InterPro

Protein Sequence (218 amino acids)

>RR42_RS12615 LexA family transcriptional regulator (Cupriavidus basilensis FW507-4G11)
MATLTPRQQQIFDLIRSSLQHTGFPPTRAEIAAKFGFSSPNAAEEHLRALARKGVIELTP
GASRGIRLKVSRSDSELPDQFSLPMAGVMQLTLPLVGRVAAGSPILAAEHIDRQYQVDAS
VFDVQPDYLLRVRGLSMRDAGILDGDLLAVKRASEAANGKIVVARLGDDVTVKRLNRRGD
IIELIAENPDFPSIIVQAGREEFSLEGIAVGLIRPSAF