Protein Info for RR42_RS12400 in Cupriavidus basilensis FW507-4G11

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 898 transmembrane" amino acids 35 to 59 (25 residues), see Phobius details amino acids 65 to 87 (23 residues), see Phobius details amino acids 104 to 137 (34 residues), see Phobius details amino acids 142 to 163 (22 residues), see Phobius details amino acids 170 to 188 (19 residues), see Phobius details amino acids 208 to 229 (22 residues), see Phobius details amino acids 249 to 280 (32 residues), see Phobius details amino acids 309 to 332 (24 residues), see Phobius details amino acids 352 to 374 (23 residues), see Phobius details amino acids 380 to 399 (20 residues), see Phobius details amino acids 416 to 438 (23 residues), see Phobius details amino acids 445 to 468 (24 residues), see Phobius details amino acids 560 to 584 (25 residues), see Phobius details amino acids 599 to 620 (22 residues), see Phobius details PF02518: HATPase_c" amino acids 784 to 897 (114 residues), 78.3 bits, see alignment E=3e-26

Best Hits

Predicted SEED Role

"Two-component hybrid sensor and regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YGS2 at UniProt or InterPro

Protein Sequence (898 amino acids)

>RR42_RS12400 histidine kinase (Cupriavidus basilensis FW507-4G11)
MRIKREYQSWVANETLEDYALRYAARSYRRWSPFTLANTAIGGVSFLALEAIGASVTLSF
GFQNAFPAILLVCALIFLIGLPVAYHASMANVDIDLLTRGAGFGYAGSTITSLIYASFTF
IFFALESAILAQALAIATGLNLTVGYLVCSLVIVPMVFFGVTLINKLQMWTQPLWAVLLV
LPFAYILRHDPGVLAQWAAFTGRDAASPAFNVLAFGAATGVLFSLMGQIGEQVDYLRFLP
DRTPRNRWSWWSALLLAGPGWIVIGGLKVLAGSLLAVLALQAGVPASHAMEPIHMYVWAY
GQVFDRPEVVLAVAMLFVLVSQIKINVTNAYAGSLAWSNVFVRLAHYHPGRVVWLVFNVL
IALLLTLLGIFSTLEAVLSVYSNLVIAWLGALVADLVVLKPLGISPRRIEFRRAYLHAFN
PVGCGAMLIASLAGIGAYSGFFGALAQAYCAFIALGASFASAILIACATRGRYYIAREDP
APLDKHTDEPIRCCICERDYEAPDMAHCPFYAGPICSLCCGLDNHCHDACKAPGAAAQVQ
AAPWQGSFLRILPPHFLRRLARFLGLFVIAAAAMGAVFLLAYRLIGEGHAAHADGIGGLL
LRVYSATLPLLAFGAWWIVLSHESRELAQAELMESLRHLESARKHLVDAEKMASLGGLVA
GVAHEINTPVGIAVSAASYLQDRTSATQALVASNGLAPEALQRYLSDAAQSARLLLSNAN
RAAELVQSFKQMAVDQTSEKRRTFDLGDYIRETVVSLDPRLRDTHVQLLIDCPAGIAMNG
YPGAVAQILTNLVMNSLVHAFGSGDTGPVRGTIRIAARLAAGDEVVIRYADDGSGIPDAL
HEKIFEPFFTSRRGKGGSGLGLHLVYNLVTQRLGGTIAVGHAGQANGGGTVFTLRMPR