Protein Info for RR42_RS11465 in Cupriavidus basilensis FW507-4G11

Annotation: pyrroloquinoline quinone biosynthesis protein PqqC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 230 TIGR02111: coenzyme PQQ biosynthesis protein C" amino acids 8 to 228 (221 residues), 336.1 bits, see alignment E=5.3e-105 PF03070: TENA_THI-4" amino acids 15 to 223 (209 residues), 157.6 bits, see alignment E=1.9e-50

Best Hits

Swiss-Prot: 71% identical to PQQC_AZOVD: Pyrroloquinoline-quinone synthase (pqqC) from Azotobacter vinelandii (strain DJ / ATCC BAA-1303)

KEGG orthology group: K06137, pyrroloquinoline-quinone synthase [EC: 1.3.3.11] (inferred from 89% identity to reu:Reut_A1780)

MetaCyc: 67% identical to pyrroloquinoline-quinone synthase monomer (Klebsiella pneumoniae)
Pyrroloquinoline-quinone synthase. [EC: 1.3.3.11]

Predicted SEED Role

"Pyrroloquinoline-quinone synthase (EC 1.3.3.11)" (EC 1.3.3.11)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.3.11

Use Curated BLAST to search for 1.3.3.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y3E9 at UniProt or InterPro

Protein Sequence (230 amino acids)

>RR42_RS11465 pyrroloquinoline quinone biosynthesis protein PqqC (Cupriavidus basilensis FW507-4G11)
MTQATAWSPAEFEARLRAKETGYHIHHPFNLRMAAGQCTPAQIRAWVANRFYYQTSIPLK
DAAVLSNCPDRATRREWVVRILDHDGTDTQEGGIEAWLRLGLAVGLTRDALWSHRHVLPG
VRFAVDAYVNFARRAPWQEAVCSSLTEMFAPEIHKERLAGWPGHYPWIEAQGLDYFRSRI
PLAQRDVDHGLRVTLGYFRTPEQQQRALDILQFKLDILWSMLDAIQLAHP