Protein Info for RR42_RS09625 in Cupriavidus basilensis FW507-4G11

Annotation: cation transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 766 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 41 to 63 (23 residues), see Phobius details amino acids 71 to 97 (27 residues), see Phobius details amino acids 235 to 254 (20 residues), see Phobius details amino acids 260 to 282 (23 residues), see Phobius details amino acids 565 to 586 (22 residues), see Phobius details amino acids 592 to 610 (19 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 69 to 611 (543 residues), 510.7 bits, see alignment E=9.2e-157 TIGR01494: HAD ATPase, P-type, family IC" amino acids 92 to 331 (240 residues), 103.5 bits, see alignment E=1.5e-33 amino acids 413 to 588 (176 residues), 111.8 bits, see alignment E=4.5e-36 PF00122: E1-E2_ATPase" amino acids 121 to 289 (169 residues), 141.5 bits, see alignment E=3.3e-45 PF00702: Hydrolase" amino acids 307 to 523 (217 residues), 78.7 bits, see alignment E=1.2e-25 PF01814: Hemerythrin" amino acids 631 to 762 (132 residues), 46.4 bits, see alignment E=8.6e-16

Best Hits

KEGG orthology group: None (inferred from 63% identity to reh:H16_A1986)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y8M6 at UniProt or InterPro

Protein Sequence (766 amino acids)

>RR42_RS09625 cation transporter (Cupriavidus basilensis FW507-4G11)
MAPAQPRYHRWLDLGLLATCALTLSAGSLLYWFESAALARTAWLIGVLPVLIALAASTVL
AAWRRKAGVDVLALLAIGFAWWLGEHFAAAVIALMLASGRALESYAQARAASEMSALLRH
APREASRFEDGEWRPVPLELVRPGDRLLVRAGEVVPADGTLLQAAELDESTLTGEAMPLR
RAPGEPLRSGVVNAGAPFEMLAGATAAQSTYSGIVRLVMAAQQSRSPSIRLADRYALLLV
PLALAVAGAAWIITGDARRALAVLVVATPCPLILAVPVAIVCGMSRAASRGILVKSGGAL
ERLAQCRVLFFDKTGTLTTGQARISAIEAAPGHAQDEVLRLAASLAQASVHASSRALVAT
ARERGLALALPGKVAEDPGAGLRGTIDGHVVTIGSLAHVASETAPTPWSTAWVRRMGHEG
ASAVFLGVDGAMCGALQLADQIRLDTPRALRLLRQAGIQRMVMLTGDREDVARMTGAMLG
VTQVRAQQTPAQKLAAIREAQRDGTVIMVGDGVNDAPALAAADVGVAMGAAGAAASAQAA
DVVLLVDRLDRLAEAMQIARRTRHIAVQSVVAGMALSLVAMIAAAFGYLPPLAGALLQEV
IDVVVILNALRARKPGPEWKPAQITAAEAARLKTEHGELGQVLDQVRSMADRVASLPGHA
AATELAALNQALREQLLAHEIHDDADLYPELARRLGGQDPLAALSGGHREIFHLVGMLER
IAADQPADGIELQSAQEIRRLLYELNAILRLHFAQEDELYHALGDV