Protein Info for RR42_RS09415 in Cupriavidus basilensis FW507-4G11

Annotation: allantoate amidohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 417 TIGR01879: amidase, hydantoinase/carbamoylase family" amino acids 25 to 415 (391 residues), 270.1 bits, see alignment E=1.5e-84 PF01546: Peptidase_M20" amino acids 78 to 414 (337 residues), 84.1 bits, see alignment E=6.6e-28

Best Hits

KEGG orthology group: K06016, N-carbamoyl-L-amino-acid hydrolase [EC: 3.5.1.87] (inferred from 70% identity to bac:BamMC406_5680)

Predicted SEED Role

"Beta-ureidopropionase (EC 3.5.1.6)" in subsystem Hydantoin metabolism or L-2-amino-thiazoline-4-carboxylic acid-Lcysteine conversion or Pyrimidine utilization (EC 3.5.1.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.6, 3.5.1.87

Use Curated BLAST to search for 3.5.1.6 or 3.5.1.87

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YET8 at UniProt or InterPro

Protein Sequence (417 amino acids)

>RR42_RS09415 allantoate amidohydrolase (Cupriavidus basilensis FW507-4G11)
MEILELKPVAEQLFKDMRELSFDGVGVTRDSYGAGETAAASYLRDFALRHGLQAQADRAA
NLVLRLPQADTGAPATWVGSHLDSVPQGGNFDGLAGIVAGLLCQFRQKRSGRHSRVPLQV
VGFRGEESAWFGKAYMGSGALLGKLSADDLALAHRHSGASLAACMTAAGADVEAIRAQAP
LLDKAKVHAYLELHIEQGPVMVARGLPVAVVPGIRGNVRHNRIQCIGEAGHSGAVPRWLR
KDAMFAVADLITRLDEHWRVLLERGIDLVVTTGVVSTSPAEHSISRIPGMVSFSFEARSK
SEETLEGFHQLLRTECKAISRDRGVRFAFDRRIESAPATMDGRLCALLTQACRQRDLPVE
PVPSGAGHDASLFANAGIPTGMLFVRNENGSHNPHEAMDIDDFLLGVQVLDDTIASL