Protein Info for RR42_RS09045 in Cupriavidus basilensis FW507-4G11

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 649 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF13624: SurA_N_3" amino acids 1 to 167 (167 residues), 139.5 bits, see alignment E=2.3e-44 PF13623: SurA_N_2" amino acids 2 to 141 (140 residues), 97.2 bits, see alignment E=2.2e-31 PF13145: Rotamase_2" amino acids 251 to 386 (136 residues), 87.4 bits, see alignment E=3.2e-28 PF13616: Rotamase_3" amino acids 270 to 373 (104 residues), 101.7 bits, see alignment E=1e-32 PF00639: Rotamase" amino acids 277 to 372 (96 residues), 100.3 bits, see alignment E=2.6e-32

Best Hits

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 81% identity to reu:Reut_A1383)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y283 at UniProt or InterPro

Protein Sequence (649 amino acids)

>RR42_RS09045 peptidylprolyl isomerase (Cupriavidus basilensis FW507-4G11)
MLDFVRNNRRLMLLLLLVLVFPSFVFFGVESYSRFMDSSHDLAKVDGRAITAQEVDNVVH
DQSERMRQMLGTNYDPRQFEGAQARQQVLDQLILQRVVADEVAKKHLTVSNERLLETISS
IPAIAQLPKKKDGTIDDKAYVGLLAQQGMTPEQFDARMRFDLATQQLSSSVGATAFVPKS
LLDRLIAIRDQQRDVQALQIKAADFTAKVNPDDAALKAYYESHKAAFSVPEQAKVDYLVL
SADALAASTPVTPEELKSYYDSNIARFRTDEQRRASHILIGSPKEAPAAERQAAKEKATK
LLEDLRKHPETFADVARKQSQDPGSAQKGGDLGFMGRGALVKPFEDAMYALKDGQISDVV
ETDYGYHIIKLTGIKPAETKPLDQVRTELEAELRKQLAAKKYTELADTFGNTVYEQSDSL
KPAADKFKLTIQSADNVTRQPNPALGAQNPLNNEKLLKALFSDDSVKNKRNTEAVQVGPT
TLVAARIVDYRPATVRKFEDVQAKVREGYIAQQAAELAAKAGAERLEALKKSGGADGFGA
PVTVSRAKADGLAPKAVEAVMRADTAKLPAYVGVDLGADGYAIYRIGKVSQPAQADAAQR
QGEAQQLGQMLGQSQLEAFYEGLKDRAKVKLLKPATTTQAGPASDAGAQ