Protein Info for RR42_RS08765 in Cupriavidus basilensis FW507-4G11

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 643 transmembrane" amino acids 18 to 41 (24 residues), see Phobius details amino acids 176 to 201 (26 residues), see Phobius details PF13675: PilJ" amino acids 38 to 131 (94 residues), 81.1 bits, see alignment E=2.3e-26 PF00672: HAMP" amino acids 196 to 243 (48 residues), 41.1 bits, see alignment 6.5e-14 PF13185: GAF_2" amino acids 282 to 427 (146 residues), 39.9 bits, see alignment E=1.7e-13 PF01590: GAF" amino acids 283 to 426 (144 residues), 27.4 bits, see alignment E=1.5e-09 PF07730: HisKA_3" amino acids 443 to 508 (66 residues), 43.2 bits, see alignment E=1.6e-14 PF13581: HATPase_c_2" amino acids 534 to 638 (105 residues), 28.1 bits, see alignment E=6.4e-10 PF02518: HATPase_c" amino acids 553 to 642 (90 residues), 37 bits, see alignment E=1.4e-12

Best Hits

KEGG orthology group: K07673, two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC: 2.7.13.3] (inferred from 67% identity to cti:RALTA_B2097)

Predicted SEED Role

"Nitrate/nitrite sensor protein (EC 2.7.3.-)" in subsystem Nitrate and nitrite ammonification (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y890 at UniProt or InterPro

Protein Sequence (643 amino acids)

>RR42_RS08765 histidine kinase (Cupriavidus basilensis FW507-4G11)
MPGQAALPGLRHRLSTRIVSLSLGALLIVLAMISGTLWLSWQLEGAGAAINDAGSLRMRA
NRVAIELARAHAGERHQLDAQITGMDATLARLRQGDPARPLFLPDDPGIRAQLERVSHDW
NQRIKPSALADLGVATGEAPAYPAALAAFVDQVNRLVSMIEQENATKTTLLRLSQAGLAA
MACMGTVAVIYLLYIWIILPVMRLQDGLQRMAAREFSLRLPVETRDEFGMLADGFNRMAG
ELEGLYQDLEARVAQKTAELARHNRDLAALYDMAALLNMPNDSEALCRGFLERVMQQFNA
DGGSVRMIDADHGQLHLVVSAGYSAALEEAEHCMRVDACFCGEAASESVVLIEDLSKGAA
LSAGRPASDARFGCAREGFPGLAVFRIETQRTVLGTFSLHFRQPLTLPASDIRLLETFGQ
HLGVALDHLHLSETARQLAVVEERNLVAQGLHDSIAQGLNYLNLQVQVLEDAVSRSDMDE
TRTIVPLLRCGVEESYQDVRELLLNFRSKLAHGELRQAVEDTVARFRRQSATELALAFND
AQGGPPLQPEQQLQVLFILQEALSNVRKHARAGHASVIVRNGRTFSMVVEDDGEGFDPME
PAADDQAHVGLHIMRERAARLSASLRIVAARGTGTRVELILPR