Protein Info for RR42_RS06285 in Cupriavidus basilensis FW507-4G11

Annotation: DNA mismatch repair protein MutS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 880 transmembrane" amino acids 617 to 636 (20 residues), see Phobius details TIGR01070: DNA mismatch repair protein MutS" amino acids 1 to 870 (870 residues), 1064.3 bits, see alignment E=0 PF01624: MutS_I" amino acids 1 to 110 (110 residues), 136.7 bits, see alignment E=1e-43 PF05188: MutS_II" amino acids 120 to 244 (125 residues), 76.9 bits, see alignment E=5.1e-25 PF05192: MutS_III" amino acids 261 to 550 (290 residues), 167 bits, see alignment E=1.7e-52 PF05190: MutS_IV" amino acids 419 to 510 (92 residues), 103.2 bits, see alignment E=1.9e-33 PF00488: MutS_V" amino acids 605 to 790 (186 residues), 276.7 bits, see alignment E=2.8e-86

Best Hits

Swiss-Prot: 74% identical to MUTS_BURA4: DNA mismatch repair protein MutS (mutS) from Burkholderia ambifaria (strain MC40-6)

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 74% identity to bac:BamMC406_1998)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y725 at UniProt or InterPro

Protein Sequence (880 amino acids)

>RR42_RS06285 DNA mismatch repair protein MutS (Cupriavidus basilensis FW507-4G11)
MMAQYLGLKADHPDTLLFYRMGDFYELFHDDAEKASRLLDITLTSRGSSNGVPIRMAGIP
FHSVDQYLARLVKLGESVAICEQIGDPATSKGPVERKVVRIVTPGTLTDAALLPDKVDTY
LMAVHQQTTRRGVSKTGLAWLNLASGELRLMECEVAQLGRELERIRPAELLYADGIELPA
LECARTRLPEWHFDQEAGTRRLREQLGVASLDPFGCAGLGAALGAAGALLNYAASTQGQS
LRHVKGVTVERESEFVGLDTATRRNLELTETLRGGESPTLFSLLDTCATAMGSRLLRHWL
HHPLRDSAIPQARQQAIGALIDQGTDALRAALRRLSDVERITARLALMNARPRDLSSLRD
TLSALPDVQACLRADDAAPLLNQTLTELAVPWECHALLASAVAPEPATVIRDGGVIARGY
DATLDELRDISENCGQFLVDLEARERTRTGIANLRVEYNRVHGFYIEVTNGQADKVPDDY
RRRQTLKNAERYITPELKVFEDKALSAQDRALVREKQLYEALLQQLLPHIGELQRVAGAL
ARLDVLAALAERAQTLDWTQPERVAENVIDLTQGRHPVVEGQLAAESVPFIANDCQLTEA
RKLLLITGPNMGGKSTFMRQTALIVLLACVGAYVPARRAVIGPIDRIFTRIGAADDLAGG
RSTFMVEMTEAASILHNATPASLVLMDEIGRGTSTFDGLALAWAIARHLLAHNRSHTLFA
THYFELTQLPQEFTQAANVHLSAVEHGDGIVFLHAVQDGPASQSYGLQVAQLAGVPQPVI
RAARKHLAWLEQQSAHATPTPQLDLFAAPPSPSDDDDDYLEQSEGEGNEGNGQPVNAISV
QQAALLDAVAELDPDSLTPRDALDALYRLRALAKDAVATA