Protein Info for RR42_RS06010 in Cupriavidus basilensis FW507-4G11
Annotation: phosphotyrosine protein phosphatase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 44% identical to Y328_SYNY3: Putative low molecular weight protein-tyrosine-phosphatase slr0328 (slr0328) from Synechocystis sp. (strain PCC 6803 / Kazusa)
KEGG orthology group: K01104, protein-tyrosine phosphatase [EC: 3.1.3.48] (inferred from 81% identity to rme:Rmet_1022)Predicted SEED Role
"Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48)" in subsystem LMPTP YfkJ cluster or LMPTP YwlE cluster (EC 3.1.3.48)
Isozymes
Compare fitness of predicted isozymes for: 3.1.3.48
Use Curated BLAST to search for 3.1.3.48
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4Y6Y6 at UniProt or InterPro
Protein Sequence (163 amino acids)
>RR42_RS06010 phosphotyrosine protein phosphatase (Cupriavidus basilensis FW507-4G11) MKKYAILMCCMGNICRSPTAEGVLRAKLEPVGLADLVELDSAGTHGYHIGRAPDARSQRH ALARGYDLCAQRARQVMAQDFARFDLLLAMDRDNLAALRAICPPGREDKLRLLMSFASRH AADEVPDPYYGEGDGFERVLDYVEDACDGVIAMLRAQGLGGAT